 |
 |
GEO help: Mouse over screen elements for information. |
|
| Status |
Public on Jun 03, 2020 |
| Title |
The CBP KIX domain regulates long-term memory and circadian activity |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Purpose: We investigated the function of the CBP KIX domain in hippocampal memory and gene expression using CBPKIX/KIX mice with mutations that prevent phospho-CREB (Ser133) binding.
Method: We performed total RNA sequencing after training for hippocampus-dependent memory from CBP KIX/KIX and WT littermates.
Results: Using an unbiased analysis of gene expression after training for hippocampus-dependent memory, we discovered dysregulation of CREB and CLOCK target genes and downregulation of circadian genes in CBPKIX/KIX mice.
Conclusion: This study provides insight into the significance of the CBP KIX domain by defining targets of CBP transcriptional co-activation in memory and the role of the CBP KIX domain in vivo on circadian rhythms.
|
| |
|
| Overall design |
Dorsal hippocampus mRNA profiles of 2-4 months old male WT and CBP KIX/KIX mice.
|
| |
|
| Contributor(s) |
Chatterjee S, Angelakos CC, Bahl E, Hawk JD, Gaine ME, Poplawski SG, Schneider-Anthony A, Yadav M, Porcari GS, Cassel JC, Giese P, Michaelson JJ, Lyons LC, Boutillier AL, Abel T |
| Citation(s) |
33121486 |
| |
| Submission date |
Jun 02, 2020 |
| Last update date |
Nov 09, 2020 |
| Contact name |
Ethan Bahl |
| E-mail(s) |
ethan-bahl@uiowa.edu
|
| Organization name |
University of Iowa
|
| Street address |
25 S Grand Ave
|
| City |
Iowa City |
| State/province |
IA |
| ZIP/Postal code |
52242 |
| Country |
USA |
| |
|
| Platforms (2) |
| GPL13112 |
Illumina HiSeq 2000 (Mus musculus) |
| GPL21103 |
Illumina HiSeq 4000 (Mus musculus) |
|
| Samples (24)
|
|
| Relations |
| BioProject |
PRJNA636822 |
| SRA |
SRP265666 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE151681_counts_all.csv.gz |
1.3 Mb |
(ftp)(http) |
CSV |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
|
|
|
|
 |
Less...
More...