|
| Status |
Public on Aug 21, 2020 |
| Title |
The site and nature of terminal bronchiolar destruction in chronic obstructive pulmonary disease (COPD). |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Previous studies have reported progressive reductions of terminal bronchioles in chronic obstructive pulmonary disease (COPD).
Based on micro-CT and Microarray profiling, this study determines the exact site of terminal bronchiole reduction and begins to investigate the gene expression patterns associated with the reduction in COPD.
|
| |
|
| Overall design |
Systematic uniform random (SUR) sampling provided 120 samples (8/lung) from 10 explanted lungs of patients with very-severe (Global Initiative for Obstructive Lung Disease, GOLD 4) COPD treated by lung transplantation, and 5 unused donor control lungs. After quality control, three samples were removed from the panel. Thus, this dataset contains the Microarray profiling of 117 samples that includes 77 COPD samples and 40 control samples.
|
| |
|
| Contributor(s) |
Xu F, Vasilescu DM, Kinose D, Tanabe N, Ng K, Coxson HO, Cooper JD, Hackett T, Verleden SE, Vanaudenaerde BM, Stevenson CS, Lenburg ME, Spira A, Sin D, Ng R, Hogg J |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
May 22, 2020 |
| Last update date |
Aug 23, 2020 |
| Contact name |
FENG XU |
| E-mail(s) |
feng.xu@hli.ubc.ca
|
| Phone |
6047818321
|
| Organization name |
UBC
|
| Department |
Department of Pathology and Lab Medicine
|
| Lab |
Jim Hogg Lab
|
| Street address |
Suite 110, 6309 Larkin Dr, 110
|
| City |
VANCOUVER |
| State/province |
BC |
| ZIP/Postal code |
V6T 0C2 |
| Country |
Canada |
| |
|
| Platforms (1) |
| GPL17556 |
[HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [HuGene10stv1_Hs_ENTREZG_17.0.0] |
|
| Samples (117)
|
|
| Relations |
| BioProject |
PRJNA634520 |
Less...
More...