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| Status |
Public on May 08, 2020 |
| Title |
The transcriptional profile of neutrophils in different organs during pancreatic cancer |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
It was previously demonstrated that myeloid cells assume a distinct transcriptional profile when infiltrating the brain during chronic inflammation. We demonstrated that neutrophils infiltrate the brain during pancreatic cancer. To determine if the transcriptional profile of brain-infiltrating neutrophils is distinct from those infiltrating other organs, we compared the gene signatures of brain-infiltrating neutrophils, circulating neutrophils, liver-infiltrating neutrophils, and tumor-infiltrating neutrophils to that of circulating neutrophils from healthy mice.
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| Overall design |
Brain-infiltrating neutrophils (n=4), Liver-infiltrating neutrophils (n=4), Tumor-infiltrating neutrophils (n=4), Circulating neutrophils (from tumor-bearing mice) (n=4), Circulating neutrophils (from sham mice) (n=4)
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| |
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| Contributor(s) |
Burfeind KG, Jeng S |
| Citation(s) |
32391790 |
| |
| Submission date |
May 07, 2020 |
| Last update date |
Jun 08, 2020 |
| Contact name |
Kevin Burfeind |
| E-mail(s) |
burfeind@ohsu.edu
|
| Organization name |
Oregon Health & Science University
|
| Street address |
3181 SW Sam Jackson Park Rd
|
| City |
Portland |
| State/province |
OR |
| ZIP/Postal code |
97239 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL17021 |
Illumina HiSeq 2500 (Mus musculus) |
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| Samples (20)
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| Relations |
| BioProject |
PRJNA631009 |
| SRA |
SRP260468 |
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