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| Status |
Public on Apr 26, 2020 |
| Title |
Genomic and physiological resilience in extreme environments are associated with a secure attachment style |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Understanding individual capability to adjust to protracted confinement and isolation may inform adaptive plasticity and disease vulnerability/resilience, and may have long-term implications for operations requiring prolonged presence in distant and restricted environments. Individual coping depends on many different factors encompassing psychological dispositional traits, endocrine reactivity and their underlying molecular mechanisms (e.g. gene expression). A positive view of self and others (secure attachment style) has been proposed to promote individual resilience under extreme environmental conditions. Here, we tested this hypothesis and investigated the underlying molecular mechanisms in 13 healthy volunteers confined and isolated for 12 months in a research station located 1670 km away from the south geographic pole on the Antarctic Plateau at 3233 m above sea level. Study participants, stratified for attachment style, were characterised longitudinally (before, during and after confinement) for their psychological appraisal of the stressful nature of the expedition, diurnal fluctuations in endocrine stress reactivity, and gene expression profiling (Agilent microarray transcriptomics). Predictably, a secure attachment style was associated with reduced psychological distress and endocrine vulnerability to stress. In addition, while prolonged confinement and isolation remarkably altered overall patterns of gene expression, such alteration was largely reduced in individuals characterized by a secure attachment style. Furthermore, increased resilience was associated with a reduced expression of genes involved in energy metabolism (mitochondrial function and oxidative phosphorylation). Ultimately, our data indicate that a secure attachment style may favour individual resilience in extreme environments and that such resilience can be mapped onto identifiable molecular substrates.
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| Overall design |
The mission crew was composed by 13 members. A total of n=49 peripheral blood samples were processed. Except few cases, 4 samples from each person were collected at 4 different time points: PRE (before mission), Day30 (30 days after mission start), Day150 (150 days after mission start), POST (after mission end). In 3 cases only it was not possible to collect all the samples, for technical reasons: in total 11,13,12,13 samples were collected at the PRE, D30, D150, POST time points respectively.
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| Contributor(s) |
Caputo V, Pacilli MG, Arisi I, Mazza T, Brandi R, Traversa A, Casasanta G, Pisa E, Sonnessa M, Healey B, Moggio L, D’Onofrio M, Alleva E, Macrì S |
| Citation(s) |
32518224 |
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| Submission date |
Apr 24, 2020 |
| Last update date |
Jul 26, 2020 |
| Contact name |
Ivan Arisi |
| E-mail(s) |
i.arisi@ebri.it
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| Phone |
+39-06-49255230
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| Organization name |
European Brain Research Institute
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| Department |
Bioinformatics Facility
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| Street address |
viale Regina Elena 295
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| City |
Roma |
| ZIP/Postal code |
00161 |
| Country |
Italy |
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| Platforms (1) |
| GPL21185 |
Agilent-072363 SurePrint G3 Human GE v3 8x60K Microarray 039494 [Probe Name Version] |
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| Samples (49)
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| Relations |
| BioProject |
PRJNA628098 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE149321_RAW.tar |
152.3 Mb |
(http)(custom) |
TAR (of TXT) |
| Processed data included within Sample table |
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