|
| Status |
Public on Apr 24, 2020 |
| Title |
Lupus milieu favors the conversion of self-reactive CD8 T cells to IL-17 producing double negative T cells |
| Organism |
Mus musculus |
| Experiment type |
Other
|
| Summary |
Mature double negative (DN) T cells are αβ T cells lacking CD4/CD8 coreceptors and expanded in patients with systemic lupus erythematosus (SLE). It is not known whether they display a narrow or expander TCR repertoire.
|
| |
|
| Overall design |
Examination of TCR repertoire of CD4, CD8 and DN T cells from lupus prone MRL/lpr mouse
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| |
|
| Contributor(s) |
Tsokos GC, Li H |
| Citation(s) |
32503973 |
| |
| Submission date |
Apr 23, 2020 |
| Last update date |
Jun 22, 2020 |
| Contact name |
George C Tsokos |
| E-mail(s) |
gtsokos@bidmc.harvard.edu
|
| Phone |
(617) 632-8658
|
| Organization name |
Harvard Medical School
|
| Department |
Rheumatology/BIDMC
|
| Street address |
CLS-928, 3 Blackfan Circle
|
| City |
Boston |
| State/province |
Massachusetts |
| ZIP/Postal code |
02115 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL19057 |
Illumina NextSeq 500 (Mus musculus) |
|
| Samples (3) |
|
| Relations |
| BioProject |
PRJNA627722 |
| SRA |
SRP258153 |
