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| Status |
Public on Aug 13, 2020 |
| Title |
Human B cell response to influenza vaccination |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
We used ultrasound-guided fine needle aspiration of the draining axillary lymph nodes to interrogate influenza vaccine-induced GC responses in humans.
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| Overall design |
Examination of 21 single-cell RNA-seq samples from PBMC and lymph node taken at multiple time points pre- and post-vaccination.
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| Contributor(s) |
Turner JS, Zhou JQ, Han J, Schmitz AJ, Rizk AA, Al-Soussi WB, Lei T, Amor M, McIntire KM, Meade P, Strohmeier S, Brent RI, Mohammed BM, Richey ST, Haile A, Yang YR, Klebert MK, Suessen T, Teefey S, Presti RM, Krammer F, Kleinstein SH, Ward AB, Ellebedy AH |
| Citation(s) |
32866963, 38935072 |
| BioProject |
PRJNA610059 |
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| Submission date |
Apr 14, 2020 |
| Last update date |
Jul 10, 2024 |
| Contact name |
Steven Kleinstein |
| Organization name |
Yale University
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| Department |
Pathology
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| Lab |
Kleinstein
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| Street address |
300 George St.
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| City |
New Haven |
| State/province |
Ct |
| ZIP/Postal code |
06511 |
| Country |
USA |
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| Platforms (1) |
| GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
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| Samples (21)
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| GSM4475901 |
scRNA-seq of Homo sapiens: adult male PBMC enriched for IgD low B cells d5 [d5_memory_B_PBMC] |
| GSM4475902 |
scRNA-seq of Homo sapiens: adult male FNA from lymph node d12 [d12_FNA_2] |
| GSM4475903 |
scRNA-seq of Homo sapiens: adult male FNA from lymph node d0 [d0_FNA] |
| GSM4475904 |
scRNA-seq of Homo sapiens: adult male PBMC enriched for IgD low B cells d28 [d28_memory_B_PBMC] |
| GSM4475905 |
scRNA-seq of Homo sapiens: adult male PBMC enriched for IgD low B cells d60 [d60_memory_B_PBMC] |
| GSM4475906 |
scRNA-seq of Homo sapiens: adult male whole PBMC d60 [d60_PBMC] |
| GSM4475907 |
scRNA-seq of Homo sapiens: adult male FNA from lymph node d0 [d0_FNA_2] |
| GSM4475908 |
scRNA-seq of Homo sapiens: adult male FNA from lymph node d5 [d5_FNA_2] |
| GSM4475909 |
scRNA-seq of Homo sapiens: adult male FNA from lymph node d5 [d5_FNA] |
| GSM4475910 |
scRNA-seq of Homo sapiens: adult male whole PBMC d0 [d0_PBMC_2] |
| GSM4475911 |
scRNA-seq of Homo sapiens: adult male FNA from lymph node d12 [d12_FNA] |
| GSM4475912 |
scRNA-seq of Homo sapiens: adult male whole PBMC d5 [d5_PBMC] |
| GSM4475913 |
scRNA-seq of Homo sapiens: adult male whole PBMC d12 [d12_PBMC_2] |
| GSM4475914 |
scRNA-seq of Homo sapiens: adult male PBMC enriched for IgD low B cells d0 [d0_memory_B_PBMC] |
| GSM4475915 |
scRNA-seq of Homo sapiens: adult male FNA from lymph node d60 [d60_FNA] |
| GSM4475916 |
scRNA-seq of Homo sapiens: adult male FNA from lymph node d12 [d12_FNA_3] |
| GSM4475917 |
scRNA-seq of Homo sapiens: adult male whole PBMC d28 [d28_PBMC_2] |
| GSM4475918 |
scRNA-seq of Homo sapiens: adult male PBMC enriched for IgD low B cells d12 [d12_memory_B_PBMC] |
| GSM4475919 |
scRNA-seq of Homo sapiens: adult male FNA from lymph node d28 [d28_FNA_3] |
| GSM4475920 |
scRNA-seq of Homo sapiens: adult male FNA from lymph node d28 [d28_FNA_2] |
| GSM4475921 |
scRNA-seq of Homo sapiens: adult male FNA from lymph node d60 [d60_FNA_2] |
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| Relations |
| SRA |
SRP251458 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE148633_aggregation.csv.gz |
459 b |
(ftp)(http) |
CSV |
| GSE148633_barcodes.tsv.gz |
665.8 Kb |
(ftp)(http) |
TSV |
| GSE148633_features.tsv.gz |
297.6 Kb |
(ftp)(http) |
TSV |
| GSE148633_matrix.mtx.gz |
756.2 Mb |
(ftp)(http) |
MTX |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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