|
| Status |
Public on Nov 12, 2020 |
| Title |
Effect of BET Inhibitors on Rheumatoid Synovial Fibroblast Cells [RNA-seq] |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
We demonstrate that JQ1 inhibits IL1B based RA Synovial Fibroblast activation and proliferation, by inhibiting key BRD2/4 superenhancer genes.
|
| |
|
| Overall design |
RNASeq of FLS cells pre and post JQ1 and IL1B treatments.
|
| |
|
| Contributor(s) |
Krishna V, Nagpal S |
| Citation(s) |
33288543 |
| |
| Submission date |
Apr 09, 2020 |
| Last update date |
Dec 15, 2020 |
| Contact name |
Vinod Krishna |
| E-mail(s) |
vkrish10@its.jnj.com
|
| Organization name |
Janssen R&D LLC
|
| Street address |
1400 McKean Road
|
| City |
Spring House |
| State/province |
Pennsylvania |
| ZIP/Postal code |
19477 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL18573 |
Illumina NextSeq 500 (Homo sapiens) |
|
| Samples (24)
|
|
| This SubSeries is part of SuperSeries: |
| GSE148404 |
Effect of BET Inhibitors on Rheumatoid Synovial Fibroblast Cells |
|
| Relations |
| BioProject |
PRJNA624140 |
| SRA |
SRP255889 |
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