NCBI Logo
GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
          Go
Series GSE148084 Query DataSets for GSE148084
Status Public on Jun 01, 2020
Title Renal gene expression in two mouse strains with different propensity to develop chronic kidney disease after subtotal nephrectomy at different time-points
Organism Mus musculus
Experiment type Expression profiling by array
Summary Renal gene expression analysis was performed in mouse strains with different propensity to develop progressive chronic kidney disease (CKD) after subtotal nephrectomy: the FVB strain which is spontaneously highly predisposed to CKD and the C57BL/6 which is spontaneously not predisposed to CKD. Subtotal nephrectomy (Nx) is normally initially compensated by proliferative tissue repair (2 days after nephrectomy). After this initial proliferation follows a quiescent period (28 days after NX). Finally, specifically in the sensitive strain there is lesion onset (53 days after Nx). Gene expression was monitored on RNA from whole kidneys from different mouse strains Sham operated or Nephrectomised at three different time-points.
 
Overall design 9 weeks old lesion-predisposed FVB mice or lesion-non-predisposed C57BL/6 mice were subjected either to Subtotal-Nephrectomy (Nx) or sham-operation (S). Gene expression was monitored at three different time points: 2, 28 and 53 days after either Subtotal Nephrectomy or Sham Operation. Gene expression was monitored on whole kidney RNA with Affymetrix microarrays.
 
Contributor(s) Zaidan M, Burtin M, Zhang JD, Blanc T, Barre P, Garbay S, Nguyen C, Vasseur F, Yammine L, Germano S, Badi L, Gubler M, Gallazzini M, Friedlander G, Pontoglio M, Terzi F
Citation(s) 32376805
Submission date Apr 03, 2020
Last update date Jul 21, 2020
Contact name Fabiola Terzi
E-mail(s) fabiola.terzi@inserm.fr
Organization name Inserm
Lab Chronic Kidney Disease
Street address Inserm U1151 CNRS U8253 Paris University, 160 rue de Vaugirard
City Paris
State/province Choisir votre état
ZIP/Postal code 75015
Country France
 
Platforms (1)
GPL1261 [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array
Samples (48)
GSM4453844 Nephrectomized; C57BL/6; 2 Days; Mouse #11
GSM4453845 Nephrectomized; C57BL/6; 2 Days; Mouse #3
GSM4453846 Nephrectomized; C57BL/6; 2 Days; Mouse #5
Relations
BioProject PRJNA623214

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE148084_RAW.tar 169.9 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table
| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap