Severe asthma is a heterogeneous disease. Transcriptomic analysis contributes to understanding the driver mechanisms necessary for developing new therapies. The aim of this study was to identify mechanistic pathways of severe asthma across two independent cohorts.
Overall design
This cross-sectional study examined transcriptomic data from endobronchial biopsies (n=73) and induced sputum (n=44) in an Australian Newcastle severe asthma cohort and the U-BIOPRED cohort.