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| Status |
Public on Feb 28, 2023 |
| Title |
Transcriptome analysis in hepatocellular carcinoma (HCC) tissues |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
Non-coding RNA profiling by high throughput sequencing
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| Summary |
We report the application of RNA sequencing technology for high-throughput profiling in HCC tissues. In the present study, to explore novel biomarkers of HCC, we firstly explored the expression profiles of mRNAs and miRNAs in three pairs of HCC patients (tumor tissues and non-tumorous tissues) by high-throughput RNA sequencing. A total of 1024 mRNAs were found to be significantly dysregulated (636 up-regulated and 388 down-regulated), 50 miRNAs were found to be significantly dysregulated (27 up-regulated and 23 down-regulated) in the HCC tissues compared with the non-tumorous tissues.Then validae the differentially expressed miRNAs by qRT-PCR in HCC tissues and serum. This study provides a framework for the application of miRNAs to be ideal biomarkers for HCC.
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| Overall design |
Examination of different expression level of mRNAs and miRNAs in HCC tissues.
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| Contributor(s) |
Sun B, Su C |
| Citation missing |
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| |
| Submission date |
Mar 10, 2020 |
| Last update date |
Feb 28, 2023 |
| Contact name |
Bin Sun |
| E-mail(s) |
sunbin05301984@aliyun.com
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| Phone |
+86-021-81875353
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| Organization name |
Eastern Hepatobiliary Surgery Hospital
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| Street address |
No.225 Changhai Road
|
| City |
Shanghai |
| ZIP/Postal code |
200438 |
| Country |
China |
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| Platforms (1) |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA611758 |
| SRA |
SRP252195 |
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