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| Status |
Public on Feb 22, 2023 |
| Title |
Impact of oligodendrocyte secreted factors on hippocampal GABAergic neurons: an electrophysiological and transcriptomic study |
| Organism |
Rattus norvegicus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
In the present work, we gain insight into the impact of oligodendrocyte secreted factors on hippocampal GABAergic neuron physiology, and performed patch-clamp recordings followed by single-cell RNA sequencing of neurons. Our results demonstrate that the GABAergic neuron excitability is influenced by glial cells and oligodendrocyte-secreted factors. Moreover, we show specific ion channels alterations and find a correlation with electrophysiological parameters suggesting possible mechanisms for the OCM-induced regulation of neuronal function.
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| Overall design |
hippocampal neurons cultured with glial cells or purified neurons treated or not with oligodendrocyte conditioned medium
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| Contributor(s) |
Mazuir E, Richevaux L, Robil N, Nassar M, de la Grange P, Lubetzki C, Fricker D, Sol-Foulon N |
| Citation missing |
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| |
| Submission date |
Mar 03, 2020 |
| Last update date |
Feb 22, 2023 |
| Contact name |
Noémie Robil |
| E-mail(s) |
noemie.robil@genosplice.com
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| Organization name |
GenoSplice technology
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| Department |
Paris Biotech Santé
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| Street address |
29, rue du Faubourg Saint-Jacques
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| City |
Paris |
| ZIP/Postal code |
75014 |
| Country |
France |
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| Platforms (1) |
| GPL20084 |
Illumina NextSeq 500 (Rattus norvegicus) |
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| Samples (21)
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| Relations |
| BioProject |
PRJNA610061 |
| SRA |
SRP251580 |
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