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| Status |
Public on Jun 17, 2020 |
| Title |
MicroRNA alterations in a mouse model of prion disease |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
MicroRNA alterations were investigated in a Tg501 mouse model of prion disases that express the goat prion protein (PRNP). Age-matched Tg501 mice without inoculation (controls) and intracranially inoculated with caprine scrapie strain were compared in presymptomatic and symptomatic stages.
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| Overall design |
Small RNA profiles from cervical spinal cord of prion-inoculated (n=11) and non-inoculated (n=13), age-matched Tg501 mice were generated at symptomatic (n=12) and presymptomatic (n=12) stage using HiSeq v4 chemistry on Illumina HiSeq 2500.
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| Contributor(s) |
Toivonen JM, Martin Burriel I |
| Citation(s) |
32549330 |
| |
| Submission date |
Feb 26, 2020 |
| Last update date |
Sep 16, 2020 |
| Contact name |
Janne M Toivonen |
| E-mail(s) |
toivonen@unizar.es
|
| Organization name |
Universidad de Zaragoza
|
| Department |
Departamento de Anatomía, Embriología y Genética Animal
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| Lab |
Laboratorio de Genética Bioquímica (LAGENBIO-I3A)
|
| Street address |
Miguel servet 177
|
| City |
Zaragoza |
| ZIP/Postal code |
50013 |
| Country |
Spain |
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| Platforms (1) |
| GPL17021 |
Illumina HiSeq 2500 (Mus musculus) |
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| Samples (24)
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| Relations |
| BioProject |
PRJNA608972 |
| SRA |
SRP250875 |
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