 |
 |
GEO help: Mouse over screen elements for information. |
|
| Status |
Public on Apr 22, 2020 |
| Title |
Single-cell landscape of bronchoalveolar immune cells in COVID-19 patients |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
Other
|
| Summary |
Immune characteristics associated with Coronavirus Disease-2019 (COVID-19) severity are currently unclear. We characterized bronchoalveolar lavage fluid (BALF) immune cells from patients with varying severity of COVID-19 disease and from healthy subjects using single-cell RNA-sequencing. Proinflammatory monocyte-derived macrophages were abundant in the BALF from severe COVID-9 patients. Moderate cases were characterized by the presence of highly clonally expanded tissue-resident CD8+ T cells. This atlas of the bronchoalveolar immune-microenvironment suggests potential mechanisms underlying pathogenesis and recovery in COVID-19.
|
| |
|
| Overall design |
Using 10x genomics to measure single-cell RNA sequence (scRNA-seq)/TCR-seq to comprehensively characterize the lung immune microenvironment in the bronchoalveolar lavage fluid (BALF) from 6 severe and 3 moderate COVID-19 patients and 3 healthy control.
|
| |
|
| Contributor(s) |
Liao M, Liu Y, Yuan J, Wen Y, Xu G, Zhao J, Cheng L, Li J, Wang X, Wang F, Liu L, Amit I, Zhang S, Zhang Z |
| Citation(s) |
32398875 |
|
medRxiv: https://doi.org/10.1101/2020.02.23.20026690
|
| |
| Submission date |
Feb 25, 2020 |
| Last update date |
Nov 30, 2020 |
| Contact name |
Zheng Zhang |
| Organization name |
Shenzhen 3rd People's Hospital
|
| Street address |
No. 29, Bulan Road
|
| City |
Shenzhen |
| State/province |
Guangdong |
| ZIP/Postal code |
454171 |
| Country |
China |
| |
|
| Platforms (1) |
|
| Samples (21)
|
|
| Relations |
| BioProject |
PRJNA608742 |
| SRA |
SRP250732 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE145926_RAW.tar |
225.1 Mb |
(http)(custom) |
TAR (of CSV, H5) |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data provided as supplementary file |
|
|
|
|
 |
Less...
More...