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| Status |
Public on Feb 19, 2020 |
| Title |
Peptidylarginine deiminase 4 promotes the renal infiltration of neutrophils and exacerbates the TLR7 agonist-induced lupus mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Peptidylarginine deiminase 4 (PAD4), encoded by PADI4, plays critical roles in the immune system. The pathological roles of PAD4 were investigated in lupus model mice. PAD4-regulated pathways were identified by RNA-sequencing of WT and Padi4 KO neutrophils.
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| Overall design |
Neutrophil mRNA profiles of 8 week-old wild type and Padi4-/-, in response to TLR7 agonost (R848), were generated.
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| Contributor(s) |
Hanata N, Shoda H, Hatano H, Nagafuchi Y, Komai T, Okamura T, Suzuki A, Gunarta IK, Yoshioka K, Yamamoto K, Fujio K |
| Citation(s) |
32655553 |
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| Submission date |
Feb 18, 2020 |
| Last update date |
Jul 22, 2020 |
| Contact name |
Hiroaki Hatano |
| E-mail(s) |
hhatano-tky@umin.ac.jp
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| Phone |
+81-3-3815-5411
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| Organization name |
The University of Tokyo
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| Department |
Department of Allergy and Rheumatology
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| Street address |
7-3-1, Hongo, Bunkyo-ku
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| City |
Tokyo |
| ZIP/Postal code |
113-8655 |
| Country |
Japan |
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| Platforms (1) |
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| Samples (8)
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| Relations |
| BioProject |
PRJNA607201 |
| SRA |
SRP249790 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE145422_htseq_result.txt.gz |
186.9 Kb |
(ftp)(http) |
TXT |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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