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Series GSE145229 Query DataSets for GSE145229
Status Public on Jun 29, 2020
Title Sex differences in neutrophil biology modulate response to type I Interferons and immunometabolism (bulkRNA-seq)
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary Differences in female and male immunity may contribute to variations in response to infections and predisposition to autoimmunity. The characterization of the mechanisms that drive differential neutrophil phenotypes between genders has been investigated. This provides new insights that distinct sex difference in neutrophil biology related to responses to type I IFNs, immunometabolism and maturation status that may have prominent functional and pathogenic implications. The transcriptome of neutrophils from healthy adult males and females was characterized using bulk RNASeq. The transcriptome of whole blood leukocytes was elucidated using scRNASeq.
Overall design The RNAseq dataset includes a total of 14 individual samples. The scRNASeq dataset includes a total of 7 individual samples. This study sought to characterize sex differences in neutrophil biology. Transcriptomic profiles of neutrophils from healthy adult males and females were characterized.
Contributor(s) Gupta S, Nakabo S, O'Neil L, Wigerblad G, Mistry P, Jiang K, Dell'Orso S, Sun HW, Kaplan MJ
Citation(s) 32601182
Submission date Feb 13, 2020
Last update date Jul 29, 2020
Contact name Mariana J. Kaplan
Organization name NIH/NIAMS
Department Systemic Autoimmunity Branch
Lab Lupus Clinical Trials Unit
Street address 9000 Rockville Pike
City Bethesda
State/province MD
ZIP/Postal code 20892
Country USA
Platforms (1)
GPL21290 Illumina HiSeq 3000 (Homo sapiens)
Samples (14)
GSM4308688 S01: mRNA_Male_Neu_01
GSM4308689 S02: mRNA_Male_Neu_02
GSM4308690 S03: mRNA_Male_Neu_03
This SubSeries is part of SuperSeries:
GSE145231 Sex differences in neutrophil biology modulate response to type I Interferons and immunometabolism
BioProject PRJNA606473
SRA SRP248938

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE145229_SG_RNA-Seq_gene_rpkm_14_samples.xlsx 3.0 Mb (ftp)(http) XLSX
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Raw data are available in SRA
Processed data are available on Series record

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