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Series GSE145106 Query DataSets for GSE145106
Status Public on May 28, 2020
Title RNA-seq of MV-4-11 or THP-1 cells treated with LSD1 inhibitor INCB059872
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary INCB059872 is a selective irreversible inhibitor of Lysine-Specific Demethylase 1 (LSD1) that is in phase 1 clinical trials in hematopoietic malignancies. LSD1 inhibition can induce differentiation of acute myeloid leukemia (AML), and here we have used RNA-seq to measure the transcriptional changes caused by INCB059872 in two AML cell lines.
Overall design Cells were treated (in duplicate) for 3hr or 24hr with INCB059872 before extracting RNA for polyA-enriched RNA-seq.
Contributor(s) Johnston G, Hiebert S
Citation(s) 32422235
Submission date Feb 11, 2020
Last update date May 28, 2020
Contact name Scott Hiebert
Organization name Vanderbilt University
Street address 2220 Pierce Ave.
City Nashville
State/province TN
ZIP/Postal code 37232
Country USA
Platforms (1)
GPL21290 Illumina HiSeq 3000 (Homo sapiens)
Samples (14)
GSM4306624 MV-4-11 control A
GSM4306625 MV-4-11 control B
GSM4306626 MV-4-11 3hr 100nM INCB059872 A
BioProject PRJNA606049
SRA SRP248224

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Supplementary file Size Download File type/resource
GSE145106_mv411_ctrl_vs_24hrLSD1i_cuffdiff_gene_exp.diff.gz 876.5 Kb (ftp)(http) DIFF
GSE145106_mv411_ctrl_vs_3hrLSD1i_cuffdiff_gene_exp.diff.gz 865.3 Kb (ftp)(http) DIFF
GSE145106_thp1_ctrl_vs_24hrLSD1i_cuffdiff_gene_exp.diff.gz 900.7 Kb (ftp)(http) DIFF
GSE145106_thp1_ctrl_vs_3hrLSD1i_cuffdiff_gene_exp.diff.gz 901.0 Kb (ftp)(http) DIFF
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