Expression profiling by high throughput sequencing
Summary
The goal of this study was to define molecular overlap between Down syndrome and Fragile X syndrome using human pluripotent stem cells (hPSCs) and in vitro derived glutamatergic neurons.
Overall design
RNA-seq was performed in FMR1y/+ ad FMR1y/- hPSCs and neurons as well as trisomy 21 and euploid control iPSCs and neurons, each with 5 biological replicates.
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