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| Status |
Public on Feb 24, 2020 |
| Title |
Genome wide anaylsis of transcriptome modifications in male mice exposed to tributyltin during development |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Purpose: To identify alterations induced by developmental exposure to tributyltin at different stages of life
Methods: Dams were treated with tributyltin during gestation and lactation in drinking water and pups were euthanized at different ages
Results: We identified a number of changes in transcriptomic activity in 5 month, and ten month old pups after tributyltin exposure. Male animals exposed to tributyltin also developed fatty liver 5 months of age and adenomas of the liver at ten months of age.
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| Overall design |
Liver was isolated from animals exposed to tributyltin during development at 5 months and 10 months. At 10 months of age adenomas were also collected.
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| Contributor(s) |
Walker C, Coarfa C |
| Citation(s) |
31939706 |
| |
| Submission date |
Jan 08, 2020 |
| Last update date |
Feb 24, 2020 |
| Contact name |
Cheryl L Walker |
| E-mail(s) |
cheryl.walker@bcm.edu
|
| Organization name |
Baylor College of Medicine
|
| Department |
Center for Precision Environmental Health
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| Street address |
1 Baylor Plaza
|
| City |
Houston |
| State/province |
TX |
| ZIP/Postal code |
77030 |
| Country |
USA |
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| Platforms (1) |
| GPL21493 |
Illumina HiSeq 3000 (Mus musculus) |
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| Samples (29)
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| Relations |
| BioProject |
PRJNA599950 |
| SRA |
SRP240390 |
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