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| Status |
Public on Mar 02, 2010 |
| Title |
Comparison of CD4+ T cell function between HIV-1 resistant and HIV-1 susceptible individuals (Affymetrix) |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Understanding why some indidivual resist HIV-1 infection despite continued exposure is an important goal for vaccine development.
We compared CD4+ T cell gene expression at baseline in HIV-1 resistant commercial sex-workers from Nairobi, Kenya to HIV-1 high-risk negative (non-resistant) commercial sex-workers using gene expression arrays
Keywords: Case-control, disease state analysis
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| Overall design |
CD4+ T cells from both HIV resistant and HIV low-risk negative individuals were isolated from PBMC after 24 hours of culture by negative slelction. Total RNA was isolated and gene expression compared using Affymetrix total genome arrays.
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| Contributor(s) |
McLaren PJ, Ball TB, Wachihi C, Jaoko W, Kelvin DJ, Danesh A, Mayne M, Greller LD, Somogyi R, Kimani J, Plummer FA, Fowke KR |
| Citation(s) |
20887221 |
| |
| Submission date |
Jan 05, 2009 |
| Last update date |
Mar 25, 2019 |
| Contact name |
Paul McLaren |
| E-mail(s) |
pmclaren@rics.bwh.harvard.edu
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| Phone |
617 525-4631
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| Organization name |
Harvard Medical School
|
| Department |
Medicine
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| Street address |
77 Avenue Louis Pasteur, NRB150
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| City |
Boston |
| State/province |
MA |
| ZIP/Postal code |
02115 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
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| Samples (18)
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| This SubSeries is part of SuperSeries: |
| GSE14280 |
Comparison of CD4+ T cell function between HIV-1 resistant and HIV-1 susceptible individuals |
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| Relations |
| BioProject |
PRJNA114563 |
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