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| Status |
Public on Feb 15, 2020 |
| Title |
RNA sequencing data of paired parental and therapy resistant cancer cell lines transfected with negative control siRNA's or a pool of siRNA's targeting DNMT1, DNMT3A and DNMT3B |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
RNA sequencing data of paired parental and therapy resistant cancer cell lines. Parental cell lines are mostly established cell lines. Resistant cell lines were obtained through long term exposure of the parental cells to gradually increasing doses of cancer therapies. Samples include 7 parental and 10 derived resistant cell lines. Our aim was to assess whether the resistant cells had undergone Epithelial to Mesenchymal Transition upon resistance acquisition and whether EMT disappears upon knock down of the DNMTs
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| Overall design |
RNA from in total 12 samples (3 parental cell lines, 3 derived resistant cell lines, each transfected with control siRNA's or siRNAs targeting the DNMTs) processed according to standard Illumina protocols.
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| Contributor(s) |
Galle E, Lambrechts D |
| Citation(s) |
32059745 |
| |
| Submission date |
Dec 25, 2019 |
| Last update date |
Feb 24, 2020 |
| Contact name |
Diether Lambrechts |
| E-mail(s) |
diether.lambrechts@kuleuven.be
|
| Organization name |
KU Leuven
|
| Department |
Human Genetics
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| Lab |
Laboratory for Translational Genetics
|
| Street address |
Herestraat 49
|
| City |
Leuven |
| ZIP/Postal code |
3000 |
| Country |
Belgium |
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| Platforms (1) |
| GPL20301 |
Illumina HiSeq 4000 (Homo sapiens) |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA597592 |
| SRA |
SRP238743 |
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