|
| Status |
Public on May 29, 2020 |
| Title |
Rational and scalable strategies to identify small “molecular glue” degraders |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
In our effort to characterize putatite novel molecular glues that we found in a phenotypic screen, we wanted to gain a more detailed understanding of the effects of these small-molecules at the trascriptome level.
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| |
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| Overall design |
KBM7 cells treated for 5h with DMSO, dCeMM-1[Hit4], dCeMM-2[Hit1], dCeMM-3[Hit2], dCeMM-4[Hit8] (10xEC50) and THZ531 (600nM). Triplicates per condition.
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| |
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| Contributor(s) |
Mayor-Ruiz C, Bauer S, Imrichova H, Winter G |
| Citation(s) |
32747809 |
| |
| Submission date |
Dec 20, 2019 |
| Last update date |
Aug 26, 2020 |
| Contact name |
Hana Imrichova |
| E-mail(s) |
hana.imrichova@gmail.com, himrichova@cemm.oeaw.ac.at
|
| Organization name |
CeMM, Vienna
|
| Street address |
Lazarettgasse 14, AKH BT 25.3
|
| City |
Vienna |
| ZIP/Postal code |
1090 |
| Country |
Austria |
| |
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| Platforms (1) |
| GPL21290 |
Illumina HiSeq 3000 (Homo sapiens) |
|
| Samples (18)
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| Relations |
| BioProject |
PRJNA596945 |
| SRA |
SRP238337 |
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