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| Status |
Public on Jun 01, 2020 |
| Title |
Transcriptome analysis of brain endothelial cells from EC-specific Glut1 knock-out pups (P6) as compared to wild type controls |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
To explore the mechanisms through which GLUT1 controls EC function, we compared transcriptomic alterations induced by loss of GLUT1 by performing RNA sequencing analysis on freshly isolated ECs from P6 GLUT1EC-/- brains. At P6, 447 genes were differentially expressed between WT and GLUT1-/- ECs. Subsequent gene set enrichment analysis showed that within the most differentially expressed pathways, several ones were related to p53, as well as inflammatory related pathways.
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| |
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| Overall design |
Examination of transcriptomic differences in GLUT1EC-/- vs WT controls
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| |
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| Contributor(s) |
Moheb G, Koen V |
| Citation(s) |
32404031 |
| |
| Submission date |
Dec 12, 2019 |
| Last update date |
Aug 10, 2020 |
| Contact name |
Katrien De Bock |
| E-mail(s) |
katrien-debock@ethz.ch
|
| Organization name |
ETH Zurich
|
| Department |
D-HEST
|
| Lab |
Lab of Exercise and Health
|
| Street address |
Schorenstrasse 16
|
| City |
Schwerzenbach |
| State/province |
Zürich |
| ZIP/Postal code |
8603 |
| Country |
Switzerland |
| |
|
| Platforms (1) |
| GPL21103 |
Illumina HiSeq 4000 (Mus musculus) |
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| Samples (8)
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| This SubSeries is part of SuperSeries: |
| GSE141926 |
Transcriptome analysis of brain endothelial cells from EC-specific Glut1 knock-out mice |
|
| Relations |
| BioProject |
PRJNA595178 |
| SRA |
SRP237346 |
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