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| Status |
Public on Dec 07, 2019 |
| Title |
Identification of osteoclast coupling factors in humans reveals links between bone remodeling and energy metabolism I |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Purpose: Identification of osteoclast derived coupling factors using Denosumab as a biological probe
Method: harvested RNA from centrifuged bone biopsies (heterogeneous population containing bone lining cells, osteoblasts, osteoclasts and osteocytes, without in vitro culture
Results: Identification of genes differentially regulated in denosumab treated participants that correlate with bone remodeling indices
Conclusions: Using this approach we identified denosumab regulated genes that correlate with bone remodeling in the untreated participants and may represent novel osteoclast derived coupling factors. Of interest, we identified DPP4 to be suppressed in denosumab treated participants, providing a novel link between bone remodeling and energy metabolism.
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| |
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| Overall design |
Examination of gene expression of centrifuged bone biopsies isolated three months after treatment with placebo or denosumab in post-menopausal women or untreated in young women.
Please note that GSM6246351-GSM6246365 sample records have been added on June 15, 2022.
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| |
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| Contributor(s) |
Weivoda M, Khosla S |
| Citation(s) |
31911667 |
| |
| Submission date |
Dec 06, 2019 |
| Last update date |
Nov 29, 2022 |
| Contact name |
Sundeep Khosla |
| Organization name |
Mayo Clinic
|
| Department |
Endocrinology Research
|
| Street address |
200 1st St SW
|
| City |
Rochester |
| State/province |
MN |
| ZIP/Postal code |
55906 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL11154 |
Illumina HiSeq 2000 (Homo sapiens) |
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| Samples (45)
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| This SubSeries is part of SuperSeries: |
| GSE141614 |
Identification of osteoclast coupling factors in humans reveals links between bone remodeling and energy metabolism. |
|
| Relations |
| BioProject |
PRJNA594028 |
| SRA |
SRP234994 |
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