|
| Status |
Public on Sep 28, 2022 |
| Title |
Transcription regulation of SNCA by dystonia type 6 gene product THAP1 [4C-Seq] |
| Organism |
Homo sapiens |
| Experiment type |
Other
|
| Summary |
The predominantly function of THAP1 has been defined as a transcription factor, but how it regulates gene expression in human neurons is not well understood. Here, we found that THAP1 is able to regulate the expression of alpha-synuclein (SNCA), a key protein in Parkinson’s disease (PD).
|
| |
|
| Overall design |
4C-seq analysis of SNCA promoter interact regions
|
| |
|
| Contributor(s) |
Cheng F, Riess O |
| Citation(s) |
35015830 |
| BioProject |
PRJNA591445 |
| |
| Submission date |
Dec 02, 2019 |
| Last update date |
Sep 29, 2022 |
| Contact name |
Fubo Cheng |
| E-mail(s) |
fubo.cheng@med.uni-tuebingen.de
|
| Organization name |
University of Tuebingen
|
| Department |
Institute of Medical Genetics and Applied Genomics
|
| Street address |
Calwerstrasse 7
|
| City |
Tuebingen |
| ZIP/Postal code |
72076 |
| Country |
Germany |
| |
|
| Platforms (1) |
| GPL18573 |
Illumina NextSeq 500 (Homo sapiens) |
|
| Samples (6)
|
|
| This SubSeries is part of SuperSeries: |
| GSE141278 |
Transcription regulation of SNCA by dystonia type 6 gene product THAP1 |
|
| Relations |
| SRA |
SRP232957 |
Less...
More...