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| Status |
Public on May 25, 2020 |
| Title |
Reduced lipolysis is a common lipid accumulation mechanism for different subtypes of lipomas |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
We used RNA-seq to inquire gene expression profiles of lipomas with HMGA2-fusions and without gene fusions. We demonstrate that HMGA2-fusions lipomas are a specific subtype and that the common shared lipid accumulation mechanism is a reduction in lipolysis, with most gene-dysregulations leading to a reduced cAMP in the adipocyte.
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| Overall design |
Characterization of lipomas and matched subcutaneous adipose tissue (SAT)
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| Contributor(s) |
Le Duc D, Lin C, Popova Y, Yang Z, Akhil V, Cakir MV, Grunewald S, Simon J, Dietz A, Dannenberger D, Schiller J, Blüher M, Rolle-Kampczyk U, von Bergen M, Kelso J, Schöneberg T |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Nov 26, 2019 |
| Last update date |
May 27, 2020 |
| Contact name |
Mehmet Volkan Cakir |
| E-mail(s) |
vlknckr@gmail.com, Mehmet.Cakir@medizin.uni-leipzig.de
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| Organization name |
Rudolf-Schonheimer-Institut fur Biochemie
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| Department |
Medical Science
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| Lab |
Schoneberg
|
| Street address |
Johannisallee 30
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| City |
Leipzig |
| State/province |
Saxony |
| ZIP/Postal code |
04103 |
| Country |
Germany |
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| Platforms (1) |
| GPL16791 |
Illumina HiSeq 2500 (Homo sapiens) |
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| Samples (30)
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| Relations |
| BioProject |
PRJNA591799 |
| SRA |
SRP233282 |
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