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Series GSE140830 Query DataSets for GSE140830
Status Public on Nov 13, 2020
Title Systems-level analysis of peripheral blood gene expression in dementia patients reveals an innate immune response shared across multiple disorders [ftd]
Organism Homo sapiens
Experiment type Expression profiling by array
Summary The role of peripheral inflammation in dementia is an important but complex topic. We present here the largest cohort of peripheral blood gene expression data ever assembled from patients with dementia and matching controls. Importantly, this cohort includes individuals from a diverse set of dementia disorders, including Alzheimer’s Disease (AD), mild cognitive impairment (MCI), and multiple disorders within the frontotemporal dementia (FTD) spectrum. We found strong transcriptional evidence of an innate immune inflammatory response, mediated by monocytes and neutrophils, in AD, MCI, and two FTD subtypes, PSP and nfvPPA. This transcriptional inflammatory response is enriched for genetic risk for AD, in part because it is also enriched for microglial genes, which have previously been implicated in AD risk. Finally, we show that this transcriptional response is strongly enriched for binding of the transcription factors PU.1 and RELA, which have previously been linked to AD risk and progression.
 
Overall design Total RNA obtained from peripheral blood in dementia patients was compared to controls. bvFTD = behavioral variant frontotemporal dementia; svPPA = semantic variant primary progressive aphasia; nfvPPA = non-fluent variant primary progressive aphasia; PSP = progressive supranuclear palsy; CBS = corticobasal syndrome
 
Contributor(s) Nachun D, Coppola G
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Submission date Nov 22, 2019
Last update date Nov 13, 2020
Contact name Daniel Nachun
Organization name UCLA
Lab Coppola
Street address 695 Charles E Young Dr S
City Los Angeles
State/province CA
ZIP/Postal code 90095
Country USA
 
Platforms (1)
GPL15988 HumanHT-12 v4 Expression BeadChip (nuID)
Samples (542)
GSM4187774 Whole blood, Control, 5872617031_A [ftd]
GSM4187775 Whole blood, Control, 5872617031_C [ftd]
GSM4187776 Whole blood, Control, 5872617031_E [ftd]
This SubSeries is part of SuperSeries:
GSE140831 Systems-level analysis of peripheral blood gene expression in dementia patients reveals an innate immune response shared across multiple disorders
Relations
BioProject PRJNA591097

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE140830_final_normalized_data.txt.gz 63.9 Mb (ftp)(http) TXT
GSE140830_raw_data.txt.gz 288.7 Mb (ftp)(http) TXT
Processed data included within Sample table
Processed data are available on Series record
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