|
| Status |
Public on Jun 21, 2024 |
| Title |
FBXW7 coordinates postprandial muscle glucose metabolism and maintenance of skeletal muscle mass |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
In this study, we show that muscle-specific inactivation of FBXW7 elicits striking defects in postprandial glucose metabolism and failure to maintain skeletal muscle mass in adult mice. Further, mice lacking FBXW7 exhibited impaired endurance capacity and exacerbated HFD-induced insulin resistance and postprandial hyperglycemia. At the mechanistic level, RNAseq and quantitative proteomic analysis revealed global effects of FBXW7 deficiency on skeletal muscle transcriptome and proteome. This work illustrates a prominent role of FBXW7 in integrating postprandial nutritional signals to coordinate glucose metabolism and muscle mass maintenance.
|
| |
|
| Overall design |
We performed RNAseq analysis on RNA isolated from quadriceps muscles of Fbxw7 muscle specific KO mice and control mice
|
| |
|
| Contributor(s) |
Wang E, Xiong X |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Nov 16, 2019 |
| Last update date |
Jun 21, 2024 |
| Contact name |
Xuelian Xiong |
| E-mail(s) |
xiong.xuelian@zs-hospital.sh.cn
|
| Organization name |
Department of Endocrinology and Metabolism
|
| Department |
Zhongshan Hospital, Fudan University
|
| Street address |
NO. 180, Fenglin Road
|
| City |
Shanghai |
| ZIP/Postal code |
200030 |
| Country |
China |
| |
|
| Platforms (1) |
| GPL21103 |
Illumina HiSeq 4000 (Mus musculus) |
|
| Samples (6)
|
|
| Relations |
| BioProject |
PRJNA589977 |
| SRA |
SRP230256 |
Less...
More...