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Series GSE140174 Query DataSets for GSE140174
Status Public on Feb 01, 2021
Title Novel Isoforms of the Epigenetic Regulator TET1 Differentially Control CNS Synaptic Function, Plasticity, and Cognition
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Methylation profiling by high throughput sequencing
Summary Two distinct Tet1 isoforms are expressed, one encoding full-length TET1 (Tet1L) and the other a truncated transcript (Tet1S), lacking a large portion of the N-terminus. Each isoform displays unique transcriptional regulation, subcellular protein localization and enzymatic activity. In neurons, Tet1L and Tet1S govern the expression and methylation levels of distinct gene ensembles that when disrupted.
Overall design In mouse hippocampal cultured neurons, Tet1L and Tet1S were selectively overexpressed and downregulated to identify loci of differential DNA methylation and gene expression.
Contributor(s) Kennedy AJ, Greer CB, Kaas GA
Citation(s) 33262245
NIH grant(s)
Grant ID Grant title Affiliation Name
P20 GM103423 Comparative Functional Genomics INBRE in Maine MDI Biological Laboratory JAMES A COFFMAN
R01 MH057014 Biochemical Mechanisms of Neural Plasticity Vanderbilt University Medical Center DANNY G. WINDER
Submission date Nov 08, 2019
Last update date Feb 01, 2021
Contact name Andrew John Kennedy
Organization name Bates College
Department Chemistry
Lab Kennedy
Street address 5 Andrews Rd, Dana 322
City Lewiston
State/province ME
ZIP/Postal code 04240
Country USA
Platforms (2)
GPL13112 Illumina HiSeq 2000 (Mus musculus)
GPL21273 HiSeq X Ten (Mus musculus)
Samples (30)
GSM4155761 NFD_TIL_1
GSM4155762 NFD_TIL_2
GSM4155763 NFD_TIL_3
BioProject PRJNA588473
SRA SRP229373

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Supplementary file Size Download File type/resource
GSE140174_RNAseq_counts_primaries_O.txt.gz 3.1 Mb (ftp)(http) TXT
GSE140174_WGBS_CpG_percent_methylation.txt.gz 51.8 Mb (ftp)(http) TXT
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Raw data are available in SRA
Processed data are available on Series record

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