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| Status |
Public on May 20, 2020 |
| Title |
Rehabilitative Impact of Exercise Training on Human Skeletal Muscle Transcriptional Programs in Parkinson’s Disease |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
We performed transcriptional profiling to test the hypotheses that a) type I myofiber grouping severity in Parkinson's disease skeletal muscle is linked to distinct gene expression networks and b) high-intensity resistance exercise rehabilitation training influences the skeletal muscle transcriptome in individuals with Parkinson's disease.
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| Overall design |
Bulk poly-A RNAseq was performed on skeletal muscle from 12 individuals with Parkinson's Disease, 12 age and sex-matched old adults, and 12 sex-matched young adults. Five of the 12 subjects with Parkinson's disease were also profiled following 16-wk of resistance training.
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| Contributor(s) |
Lavin KM, Ge Y, Sealfon SC, McDonald MN, Wilk K, Nair VD, McAdam JS, Kumar PL, Windham ST, Bamman MM |
| Citation(s) |
32625117 |
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| Submission date |
Nov 07, 2019 |
| Last update date |
Jul 07, 2020 |
| Contact name |
Yongchao Ge |
| E-mail(s) |
yongchao.ge@gmail.com
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| Organization name |
Icahn School of Medicine at Mount Sinai
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| Department |
Neurology
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| Street address |
One Gustave L Levy Place #1137
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| City |
New York |
| State/province |
NY |
| ZIP/Postal code |
10029 |
| Country |
USA |
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| Platforms (1) |
| GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
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| Samples (41)
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| GSM4154223 |
Skeletal Muscle, M-M-04 |
| GSM4154224 |
Skeletal Muscle, M-M-05 |
| GSM4154225 |
Skeletal Muscle, M-M-06 |
| GSM4154226 |
Skeletal Muscle, M-M-07 |
| GSM4154227 |
Skeletal Muscle, M-M-08 |
| GSM4154228 |
Skeletal Muscle, M-M-09 |
| GSM4154229 |
Skeletal Muscle, M-M-10 |
| GSM4154230 |
Skeletal Muscle, M-M-11 |
| GSM4154231 |
Skeletal Muscle, M-M-12 |
| GSM4154232 |
Skeletal Muscle, M-M-13 |
| GSM4154233 |
Skeletal Muscle, M-M-14 |
| GSM4154234 |
Skeletal Muscle, M-M-15 |
| GSM4154235 |
Skeletal Muscle, M-M-16 |
| GSM4154236 |
Skeletal Muscle, M-M-17 |
| GSM4154237 |
Skeletal Muscle, M-M-18 |
| GSM4154238 |
Skeletal Muscle, M-M-19 |
| GSM4154239 |
Skeletal Muscle, M-M-20 |
| GSM4154240 |
Skeletal Muscle, M-M-21 |
| GSM4154241 |
Skeletal Muscle, M-M-22 |
| GSM4154242 |
Skeletal Muscle, M-M-23 |
| GSM4154243 |
Skeletal Muscle, M-M-24 |
| GSM4154244 |
Skeletal Muscle, M-M-25 |
| GSM4154245 |
Skeletal Muscle, M-M-26 |
| GSM4154246 |
Skeletal Muscle, M-M-27 |
| GSM4154247 |
Skeletal Muscle, M-M-28 |
| GSM4154248 |
Skeletal Muscle, M-M-29 |
| GSM4154249 |
Skeletal Muscle, M-M-30 |
| GSM4154250 |
Skeletal Muscle, M-M-31 |
| GSM4154251 |
Skeletal Muscle, M-M-32 |
| GSM4154252 |
Skeletal Muscle, M-M-33 |
| GSM4154253 |
Skeletal Muscle, M-M-34 |
| GSM4154254 |
Skeletal Muscle, M-M-35 |
| GSM4154255 |
Skeletal Muscle, M-M-36 |
| GSM4154256 |
Skeletal Muscle, M-M-37 |
| GSM4154257 |
Skeletal Muscle, M-M-38 |
| GSM4154258 |
Skeletal Muscle, M-M-39 |
| GSM4154259 |
Skeletal Muscle, M-M-40 |
| GSM4154260 |
Skeletal Muscle, M-M-41 |
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| Relations |
| BioProject |
PRJNA588234 |
| SRA |
SRP229091 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE140089_featureCounts.txt.gz |
2.0 Mb |
(ftp)(http) |
TXT |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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