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Series GSE140089 Query DataSets for GSE140089
Status Public on May 20, 2020
Title Rehabilitative Impact of Exercise Training on Human Skeletal Muscle Transcriptional Programs in Parkinson’s Disease
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary We performed transcriptional profiling to test the hypotheses that a) type I myofiber grouping severity in Parkinson's disease skeletal muscle is linked to distinct gene expression networks and b) high-intensity resistance exercise rehabilitation training influences the skeletal muscle transcriptome in individuals with Parkinson's disease.
Overall design Bulk poly-A RNAseq was performed on skeletal muscle from 12 individuals with Parkinson's Disease, 12 age and sex-matched old adults, and 12 sex-matched young adults. Five of the 12 subjects with Parkinson's disease were also profiled following 16-wk of resistance training.
Contributor(s) Lavin KM, Ge Y, Sealfon SC, McDonald MN, Wilk K, Nair VD, McAdam JS, Kumar PL, Windham ST, Bamman MM
Citation(s) 32625117
Submission date Nov 07, 2019
Last update date Jul 07, 2020
Contact name Yongchao Ge
Organization name Icahn School of Medicine at Mount Sinai
Department Neurology
Street address One Gustave L Levy Place #1137
City New York
State/province NY
ZIP/Postal code 10029
Country USA
Platforms (1)
GPL24676 Illumina NovaSeq 6000 (Homo sapiens)
Samples (41)
GSM4154220 Skeletal Muscle, M-M-01
GSM4154221 Skeletal Muscle, M-M-02
GSM4154222 Skeletal Muscle, M-M-03
BioProject PRJNA588234
SRA SRP229091

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Supplementary file Size Download File type/resource
GSE140089_featureCounts.txt.gz 2.0 Mb (ftp)(http) TXT
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Processed data are available on Series record

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