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| Status |
Public on Nov 06, 2019 |
| Title |
miRNome changes in the mouse kidney, LPS-administered vs. control |
| Platform organisms |
Homo sapiens; Mus musculus; Rattus norvegicus |
| Sample organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Comparing control and LPS-administered with either 40 mg/kg LPS for early time points (ETP) or 10 mg/kg for late time points (LTP). In ETP, 7-7 animals were sacrificed at 1.5 and at 6 hours after LPS administration. In LTP, 7-7 animals were sacrificed at 24 and 48 hours after the endotoxin injection. In both ETP and LTP 7 mice were received equal volume of saline to use as negative control. Four animals were selected for miRNA microArray analysis based on their proinflammatory (TNF-α and IL-6) mRNA expression levels.
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| Overall design |
Two-condition design: saline and LPS administration with 2-2 endpoints, n=4 animals/dose and time point and n= 4 control
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| Contributor(s) |
Tod P, Szénási G, Kaucsár T, Róka B, Hamar P |
| Citation(s) |
32727087 |
| |
| Submission date |
Nov 05, 2019 |
| Last update date |
Aug 31, 2020 |
| Contact name |
Pál Tod |
| E-mail(s) |
todpal90@gmail.com
|
| Phone |
+36205070038
|
| Organization name |
Institute of Experimental Medicine
|
| Lab |
Laboratory of Molecular Pharmacology
|
| Street address |
Szigony utca 43
|
| City |
Budapest |
| State/province |
Budapest |
| ZIP/Postal code |
H-1083 |
| Country |
Hungary |
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| Platforms (1) |
| GPL27719 |
Exiqon miRCURY LNA microRNA Array 7th generation (miRBase 19.0) |
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| Samples (20)
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| Relations |
| BioProject |
PRJNA587628 |
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