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| Status |
Public on Oct 24, 2019 |
| Title |
TIP60/KAT5 is required for neuronal viability in hippocampal CA1 |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
We aimed at investigating the function of TIP60 in the in the mammalian hippocampus. For this, we used mice with a forebrain-specific deletion of Tip60 upon tamoxifen injection (Tip60 cKO). RNA-sequencing was applied to examine the transcriptome changes in the CA1 region upon Tip60 deletion. We observed massive transcriptional changes and identified a neurodegeneration-related signature at a time when there are no obvious morphological changes in Tip60 cKO mice. Later on these mice develop extensive neurodegeneration in hippocampal CA1.
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| Overall design |
We profiled gene expression levels through RNA-Seq to compare Tip60 cKOs to control mice 10 days after tamoxifen injections.
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| Contributor(s) |
Wang H, Urban I |
| Citation(s) |
31700011 |
| |
| Submission date |
Oct 23, 2019 |
| Last update date |
Jan 23, 2020 |
| Contact name |
Haifang Wang |
| E-mail(s) |
wanghf@ion.ac.cn
|
| Phone |
+8615901957241
|
| Organization name |
Institute of Neuroscience
|
| Street address |
NO 320, Yue Yang Road
|
| City |
Shanghai |
| ZIP/Postal code |
200031 |
| Country |
China |
| |
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| Platforms (1) |
| GPL9185 |
Illumina Genome Analyzer (Mus musculus) |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA579152 |
| SRA |
SRP226737 |
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