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| Status |
Public on Dec 08, 2021 |
| Title |
Study on gene expression profiles of peripheral blood mononuclear cells from patients with atopic dermatitis stimulated by Malassezia globosa |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Malassezia is considered to be involved in the pathogenesis of atopic dermatitis (AD). However, the specific role of Malassezia in the pathogenesis of AD is still unclear, as the current studies mainly focus on the mechanism of immune responses induced by it. The studies on specific molecular mechanisms are insufficient, which is unfavorable to in-depth understand the influence of Malassezia on host immune cells.
We used microarrays to detect the influence of M. globosa on the gene expression of peripheral blood mononuclear cells (PBMCs) from AD patients.
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| Overall design |
PBMCs were extracted from 3 cases of patients with severe AD and 3 cases of healthy control subjects by density gradient centrifugation. PBMCs were stimulated with M. globosa, establishing their own negative controls. The Affymetrix Human Prime View array was used to analyze the changes in gene expression.
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| Contributor(s) |
Lu M, Ran Y |
| Citation(s) |
34039870 |
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| Submission date |
Oct 22, 2019 |
| Last update date |
Dec 09, 2021 |
| Contact name |
Mao Lu |
| E-mail(s) |
2680550218@qq.com
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| Phone |
+86-13678168632
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| Organization name |
The First Affiliated Hospital, Chengdu Medical College, Chengdu, China
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| Department |
Department of Dermatovenereology,
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| Street address |
Baoguang Road middle segment
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| City |
Xindu district, Chengdu city |
| State/province |
Sichuan |
| ZIP/Postal code |
610500 |
| Country |
China |
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| Platforms (1) |
| GPL15207 |
[PrimeView] Affymetrix Human Gene Expression Array |
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| Samples (12)
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| GSM4134599 |
non-stimulated PBMCs of AD, biological rep1 |
| GSM4134600 |
non-stimulated PBMCs of AD, biological rep2 |
| GSM4134601 |
non-stimulated PBMCs of AD, biological rep3 |
| GSM4134602 |
non-stimulated PBMCs of HC, biological rep1 |
| GSM4134603 |
non-stimulated PBMCs of HC, biological rep2 |
| GSM4134604 |
non-stimulated PBMCs of HC, biological rep3 |
| GSM4134605 |
stimulated PBMCs of AD, biological rep1 |
| GSM4134606 |
stimulated PBMCs of AD, biological rep2 |
| GSM4134607 |
stimulated PBMCs of AD, biological rep3 |
| GSM4134608 |
stimulated PBMCs of HC, biological rep1 |
| GSM4134609 |
stimulated PBMCs of HC, biological rep2 |
| GSM4134610 |
stimulated PBMCs of HC, biological rep3 |
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| Relations |
| BioProject |
PRJNA578895 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE139247_RAW.tar |
23.1 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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