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Series GSE139024 Query DataSets for GSE139024
Status Public on Apr 30, 2020
Title Ectopic Tcf1 expression reprograms exhausted CD8+ T cells to acquire stem cell-like features [ATAC-seq]
Organism Mus musculus
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary The goal of this study is to determine the capacity of Tcf1 to reprogram exhausted CD8+ T cells for function restoration. Tex cells elicited by chronic infection contain a CXCR5+Tim3– subset that has stem cell-like self-renewing capacity and expresses an elevated level of Tcf1 (termed Tex-stem), and Tex-stem cells depend on Tcf1 for generation and persistence. We show that ectopic Tcf1 expression profoundly affected the chromatin accessibility of Tex cells.
 
Overall design Genome-wide chromatin accessibility profiles of stem cell-like exhauseted CD8+ T cells with or without ectopic Tcf1 expression.
 
Contributor(s) Qiang S, Sheng'en H, Chongzhi Z, Hai-Hui X
Citation(s) 32341523
Submission date Oct 17, 2019
Last update date Apr 30, 2020
Contact name Haihui Xue
E-mail(s) haihui.xue@hmh-cdi.org
Organization name Hackensack University Medial Center
Department Center for Discovery and Innovation
Lab Xue lab
Street address 111 Ideation Way
City Nutley
State/province NJ
ZIP/Postal code 07110
Country USA
 
Platforms (1)
GPL21273 HiSeq X Ten (Mus musculus)
Samples (6)
GSM4126964 CD8TexStem_p45Tg_ATAC_r1
GSM4126965 CD8TexStem_p45Tg_ATAC_r2
GSM4126966 CD8TexStem_WT_ATAC_r1
This SubSeries is part of SuperSeries:
GSE139058 Ectopic Tcf1 expression reprograms exhausted CD8+ T cells to acquire stem cell-like features
Relations
BioProject PRJNA578114
SRA SRP226072

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE139024_RAW.tar 706.6 Mb (http)(custom) TAR (of BW)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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