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Series GSE139024 Query DataSets for GSE139024
Status Public on Apr 30, 2020
Title Ectopic Tcf1 expression reprograms exhausted CD8+ T cells to acquire stem cell-like features [ATAC-seq]
Organism Mus musculus
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary The goal of this study is to determine the capacity of Tcf1 to reprogram exhausted CD8+ T cells for function restoration. Tex cells elicited by chronic infection contain a CXCR5+Tim3– subset that has stem cell-like self-renewing capacity and expresses an elevated level of Tcf1 (termed Tex-stem), and Tex-stem cells depend on Tcf1 for generation and persistence. We show that ectopic Tcf1 expression profoundly affected the chromatin accessibility of Tex cells.
Overall design Genome-wide chromatin accessibility profiles of stem cell-like exhauseted CD8+ T cells with or without ectopic Tcf1 expression.
Contributor(s) Qiang S, Sheng'en H, Chongzhi Z, Hai-Hui X
Citation(s) 32341523
Submission date Oct 17, 2019
Last update date Apr 30, 2020
Contact name Haihui Xue
Organization name Hackensack University Medial Center
Department Center for Discovery and Innovation
Lab Xue lab
Street address 111 Ideation Way
City Nutley
State/province NJ
ZIP/Postal code 07110
Country USA
Platforms (1)
GPL21273 HiSeq X Ten (Mus musculus)
Samples (6)
GSM4126964 CD8TexStem_p45Tg_ATAC_r1
GSM4126965 CD8TexStem_p45Tg_ATAC_r2
GSM4126966 CD8TexStem_WT_ATAC_r1
This SubSeries is part of SuperSeries:
GSE139058 Ectopic Tcf1 expression reprograms exhausted CD8+ T cells to acquire stem cell-like features
BioProject PRJNA578114
SRA SRP226072

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE139024_RAW.tar 706.6 Mb (http)(custom) TAR (of BW)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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