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| Status |
Public on Nov 11, 2019 |
| Title |
Dysregulation of different classes of tRNA fragments in chronic lymphocytic leukemia |
| Organism |
Homo sapiens |
| Experiment type |
Non-coding RNA profiling by high throughput sequencing
|
| Summary |
We analyzed small RNA sequencing data from CD5+/CD19+ B cells of a cohort of indolent and aggressive CLL patients compared with CD19+ B-cells of healthy donors.
We identified tsRNA signatures in indolent and aggressive CLL vs. normal B-cells; we also found a drastic dysregulation of the expression of mature tRFs in CLL.
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| Overall design |
A total of 20 whole blood samples provided by the CLL Research Consortium and grouped into the following two categories: 10 indolent CLL and 10 aggressive CLL. A third category of 8 CD19+ B-cell control samples (courtesy of J. Byrd MD, IRB approved protocol) was also considered in the study.
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| Contributor(s) |
Perkarsky Y, Croce CM |
| Citation(s) |
31723042 |
| |
| Submission date |
Oct 15, 2019 |
| Last update date |
Feb 10, 2020 |
| Contact name |
Carlo Maria Croce |
| E-mail(s) |
carlo.croce@osumc.edu
|
| Organization name |
The Ohio State University
|
| Department |
Cancer Biology & Genetics
|
| Lab |
1082 Biomedical Research Tower
|
| Street address |
460 West 12TH Avenue
|
| City |
Columbus |
| State/province |
OHIO |
| ZIP/Postal code |
43210 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL16791 |
Illumina HiSeq 2500 (Homo sapiens) |
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| Samples (28)
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| Relations |
| BioProject |
PRJNA577689 |
| SRA |
SRP225755 |
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