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Series GSE138878 Query DataSets for GSE138878
Status Public on Feb 19, 2020
Title Regulating lineage progression of cortical neural stem cells by extrinsic signaling molecule SHH [bulk RNA-seq]
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Purpose:To asses changes in gene expression profiles from the P0 wild type littermate controls cortex, hGFAP-Cre, SmoM2f/+ mice cortex and ShhN IUE (ShhN palsmid were electroporated to wild type mice cortex at E13.5 and the cortex were dissected at P0) mice.
Methords:Total RNA was isolated and sequenced using an illumina high-seq 2500. Raw data was analyzed using TopHat. Genes were considered significantly changed whicn perform fold-change>=2 and P value <= 0.05
Results: Compared to controls, 2466 genes were significantly down-regulated, and 5289 genes were up regulated in the RNA expression level of the SmoM2 mice; 3492 genes were significantly down-regulated, and 3577 genes were up regulated in the RNA expression level of the cortex of ShhN IUE mice.
Overall design Cortex RNA profiles of P0 Wild type mice brain, ShhN IUE mice brain and hGFAP-Cre, SmoM2f/+ mice brain
Contributor(s) Zhang Y, Liu G, Guo T, Liang XG, Du H, Yang L, Bhaduri A, Li X, Xu Z, Zhang Z, Li Z, He M, Tsyporin J, Kriegstein AR, Rubenstein JL, Yang Z, Chen B, Yang Z, Chen B
Citation(s) 32234482
Submission date Oct 15, 2019
Last update date May 20, 2020
Contact name Guoping Liu
Phone 18521006300
Organization name Fudan University
Street address 138 Yi Xue Yuan Road
City Shanghai
ZIP/Postal code 200032
Country China
Platforms (1)
GPL17021 Illumina HiSeq 2500 (Mus musculus)
Samples (9)
GSM4120835 Wild type rep 1
GSM4120836 Wild type rep 2
GSM4120837 Wild type rep 3
This SubSeries is part of SuperSeries:
GSE140817 Cortical Neural Stem Cell Lineage Progression Is Regulated by Extrinsic Signaling Molecule Sonic Hedgehog
BioProject PRJNA577670
SRA SRP225731

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE138878_all.counts.WT_vs_ShhN_IUE_all.txt.gz 10.6 Mb (ftp)(http) TXT
GSE138878_all.counts.WT_vs_hGFAP-cre_SmoM2_all.txt.gz 10.8 Mb (ftp)(http) TXT
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Raw data are available in SRA
Processed data are available on Series record

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