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Series GSE138438 Query DataSets for GSE138438
Status Public on Mar 09, 2021
Title Copy-number profiling by SNP array of 4 acute myeloid leukemia (AML) cell lines
Organism Homo sapiens
Experiment type Genome variation profiling by SNP array
Summary DNMT inhibitors (DNMTi) are finally approved for AML/MDS, also based on their activity in patients with high-risk cytogenetics (often monosomal karyotype) such as -5/del(5q) or -7/del(7q), often - but not always - harboring TP53-mutations. Several studies provided evidence for aberrant hypermethylation/silencing on monoallelic gene loci, including tumor suppressor genes. We hypothesized that transcriptional repression on monosomal gene loci may be preferentially reversed by DNMTi. Using an unbiased RNA-seq approach we aimed to identify preferentially regulated genes in cells monoallelic for chromosome 7q.
 
Overall design Affymetrix SNP arrays were performed according to the manufacturer's protocol on DNA extracted from the cultured AML cell lines UCSD-AML1, ELF-153, KG-1 and U937.
Web link https://cancerres.aacrjournals.org/content/81/4/834.long
 
Contributor(s) Greve G, Pfeifer D
Citation(s) 33203699
Submission date Oct 04, 2019
Last update date Mar 11, 2021
Contact name Gabriele Greve
E-mail(s) gabriele.greve@uniklinik-freiburg.de
Organization name University of Freiburg Medical Center
Department Department of Internal Medicine 1
Lab Division of Hematology, Oncology and SCT, Lab Prof. Michael L├╝bbert
Street address Hugstetter Str 55
City Freiburg
ZIP/Postal code 79106
Country Germany
 
Platforms (2)
GPL6801 [GenomeWideSNP_6] Affymetrix Genome-Wide Human SNP 6.0 Array
GPL18637 [CytoScan750K_Array] Affymetrix CytoScan 750K Array
Samples (4)
GSM4107987 Acute myeloid leukemia cell line UCSD-AML1
GSM4107988 Acute myeloid leukemia cell line ELF-153
GSM4107989 Acute myeloid leukemia cell line KG-1
Relations
BioProject PRJNA575864

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE138438_RAW.tar 293.5 Mb (http)(custom) TAR (of CEL, CNCHP, CYCHP)
Processed data provided as supplementary file

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