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| Status |
Public on Sep 16, 2020 |
| Title |
SIRT7 safeguards genome stability and suppresses colorectal tumorigenesis |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
SIRT7 is a member of the mammalian sirtuin family and functions as a NAD+-dependent deacylase. Studies in culture cells and human clinical data have implicated the role of SIRT7 in tumorigenesis. However, controversies were raised as to whether SIRT7 is oncogenic or tumor suppressive. Here we show that SIRT7 deficiency led to aneuploidy and aging-phenotypes, including senescence and nucleolin expansion. SIRT7 knockout mice were susceptible to DSS-induced colitis and alcohol-derived DNA damage, in advance led to intestinal epithelial barrier disruption. Devoid of SIRT7 aggravated the susceptibility of colorectal cancer incidence in APCMin/+ mouse model with further dysregulated Wnt signaling. Our findings indicated a tumor suppressive role of SIRT7 in vivo, novel strategies design for activating SIRT7 in treating colon cancer may be reappraised.
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| Overall design |
Intestinal mRNA profiles of three 5-month old Apc min/+ (Apc min/+) versus APC min/+ ; Sirt7 -/- (Apc min/+;Sirt7KO) mice.
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| |
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| Contributor(s) |
Tang Y, Chang H |
| Citation(s) |
32861997 |
| |
| Submission date |
Oct 02, 2019 |
| Last update date |
Sep 16, 2020 |
| Contact name |
Xiyang Liu |
| E-mail(s) |
liuxy@sibs.ac.cn
|
| Organization name |
Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences
|
| Lab |
Laboratory of Cancer Biology and Genetics
|
| Street address |
320 Yueyang Road, Shanghai, 20025 P.R. China
|
| City |
Shanghai |
| State/province |
Shanghai |
| ZIP/Postal code |
200031 |
| Country |
China |
| |
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| Platforms (1) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA575347 |
| SRA |
SRP223932 |
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