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Series GSE138289 Query DataSets for GSE138289
Status Public on Sep 16, 2020
Title SIRT7 safeguards genome stability and suppresses colorectal tumorigenesis
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary SIRT7 is a member of the mammalian sirtuin family and functions as a NAD+-dependent deacylase. Studies in culture cells and human clinical data have implicated the role of SIRT7 in tumorigenesis. However, controversies were raised as to whether SIRT7 is oncogenic or tumor suppressive. Here we show that SIRT7 deficiency led to aneuploidy and aging-phenotypes, including senescence and nucleolin expansion. SIRT7 knockout mice were susceptible to DSS-induced colitis and alcohol-derived DNA damage, in advance led to intestinal epithelial barrier disruption. Devoid of SIRT7 aggravated the susceptibility of colorectal cancer incidence in APCMin/+ mouse model with further dysregulated Wnt signaling. Our findings indicated a tumor suppressive role of SIRT7 in vivo, novel strategies design for activating SIRT7 in treating colon cancer may be reappraised.
Overall design Intestinal mRNA profiles of three 5-month old Apc min/+ (Apc min/+) versus APC min/+ ; Sirt7 -/- (Apc min/+;Sirt7KO) mice.
Contributor(s) Tang Y, Chang H
Citation(s) 32861997
Submission date Oct 02, 2019
Last update date Sep 16, 2020
Contact name Xiyang Liu
Organization name Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences
Lab Laboratory of Cancer Biology and Genetics
Street address 320 Yueyang Road, Shanghai, 20025 P.R. China
City Shanghai
State/province Shanghai
ZIP/Postal code 200031
Country China
Platforms (1)
GPL21273 HiSeq X Ten (Mus musculus)
Samples (6)
GSM4104530 APC min/+_1
GSM4104531 APC min/+_2
GSM4104532 APC min/+_3
BioProject PRJNA575347
SRA SRP223932

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Supplementary file Size Download File type/resource
GSE138289_WT_vs_KO_DEseq2_all_merge_counts_norm.xlsx 3.8 Mb (ftp)(http) XLSX
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