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Series GSE138096 Query DataSets for GSE138096
Status Public on Oct 28, 2020
Title Next Generation Sequencing Facilitates Quantitative Analysis of Wild Type and Diabetic db/db Mice Islets Transcriptomes
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Non-coding RNA profiling by high throughput sequencing
Summary Circular RNAs constitute an extensive fraction of the mammalian transcriptome.In this study, circular RNAs dysregulated in the islets of diabetic db/db mice were identified by high-throughput RNA sequencing. More than 5000 circRNAs were detected using RNA sequencing, indicating that circular transcripts were abundant in islets. Among them, we found that circ-Tulp4 showed significant downregulation in diabetic mouse islet cells. Further experiments indicated that modulating the expression of circ-Tulp4 in β cell lines desensitized β-cells to lipotoxicity.
Overall design Islet circRNAs and mRNA profiling in db/db and db/m control mice were generated by deep sequencing, in triplicate, using Illumina Hiseq.
Contributor(s) Wu L, Xiong L
Citation(s) 33064661
Submission date Sep 27, 2019
Last update date Oct 28, 2020
Contact name Liting Wu
Organization name The First Affiliated Hospital of Sun Yat-sen University
Department Department of Endocrinology and Metabolism
Street address Zhongshan Road 2
City Guangzhou
ZIP/Postal code 510080
Country China
Platforms (1)
GPL21273 HiSeq X Ten (Mus musculus)
Samples (6)
GSM4099246 db/db1
GSM4099247 db/db2
GSM4099248 db/db3
BioProject PRJNA574600
SRA SRP223504

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Supplementary file Size Download File type/resource
GSE138096_all.counts.exp.txt.gz 336.4 Kb (ftp)(http) TXT
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