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Series GSE137829 Query DataSets for GSE137829
Status Public on Sep 01, 2020
Title Single-cell analysis supports a luminal-neuroendocrine transdifferentiation in human prostate cancer
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary Neuroendocrine prostate cancer (NEPC) is a subset of castration-resistant prostate cancer (CRPC) and is thought to derive from prostate adenocarcinoma. However, the cellular basis responsible for Neuroendocrine differentiation (NED) is still under debate. Here, we characterized the tumor cell diversity of 6 CRPC patients using single cell RNA sequencing (scRNA-seq) and detected NED in four patients.
Overall design Single cell mRNA profiles of 6 CRPC patients were generated by 10X Genomics plartform, without technical replication, and sequenced by NovaSeq 6000 (Illumina)
Contributor(s) Wang J, Gao W
Citation(s) 33328604, 37092583
Submission date Sep 23, 2019
Last update date Sep 08, 2023
Contact name Jia Wang
Phone 15821724825
Organization name SJTU CHINA
Street address Huashan Rd. 1940, build 3. Shanghai,
City Shanghai
State/province Shanghai China
ZIP/Postal code 200017
Country China
Platforms (1)
GPL24676 Illumina NovaSeq 6000 (Homo sapiens)
Samples (6)
GSM4089151 Patient #1-scRNA
GSM4089152 Patient #2-scRNA
GSM4089153 Patient #3-scRNA
BioProject PRJNA573608
SRA SRP222939

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE137829_RAW.tar 76.7 Mb (http)(custom) TAR (of TXT)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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