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| Status |
Public on May 19, 2020 |
| Title |
Effects of exercise training on skeletal muscle insulin sensitivity in obesity patients undergoing RYGB surgery: a randomized controlled trial |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
We reported that skeletal muscle insulin sensitivity was restored to a lean phenotype with exercise training in patients undergoing RYGB surgery. For that, the goals of this study is to identify changes in the skeletal muscle transcriptome profiling (RNA-seq) that could explain the insulin sensitivity improvement of RYGB + exercise training group.
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| Overall design |
Women patients with morbid obesity were undergone to RYGB and randomized to exercise training or not. Muscle biopsies were assessed before the RYGB surgery (PRE) and 9-month after RYGB surgery in both groups (RYGB and RYGB + exercise training). At baseline (PRE), muscle samples from lean control women were obtained as well.
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| Contributor(s) |
Kirwan JP, Dantas WS, Ghosh S, Carmouche RP, Newman SS, Webb SM, Gualano B |
| Citation(s) |
32409493, 34666419 |
| |
| Submission date |
Sep 18, 2019 |
| Last update date |
Oct 25, 2021 |
| Contact name |
Wagner S. Dantas |
| E-mail(s) |
wagnersilvadantas@gmail.com
|
| Phone |
2252840653
|
| Organization name |
Pennington Biomedical Research Center
|
| Street address |
6400 Perkins Road
|
| City |
Baton Rouge |
| State/province |
LA |
| ZIP/Postal code |
70808 |
| Country |
USA |
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| Platforms (1) |
| GPL18573 |
Illumina NextSeq 500 (Homo sapiens) |
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| Samples (30)
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| Relations |
| BioProject |
PRJNA566111 |
| SRA |
SRP222279 |
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