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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Jun 30, 2021 |
| Title |
RNA-seq of C3H/He mice on the American Lifestyle diet (ALIOS) |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
We have developed a novel murine model of Diet-induced HCC via feeding the C3H/He mouse strain with the American life style diet (ALIOS) for 48 weeks. RNAseq was performed to the developed tumors as well as the non-tumor tissue of mice livers seeking for understanding the contributing pathways to the development and the progression of HCC in this mice strain. We also investigated whether the tumors developed in mice recaptiulate any particular human HCC subclass.
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| Overall design |
RNA-seq of non-tumor and tumor tissues of mice fed on Amercan lifestyle diet and control diet with/without concurrent admistration of the liver carcinogen DEN
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| Contributor(s) |
Zaki MY, Mahdi AK, Patman GL, Whitehead A, Mauricio J, McCain MV, Televantou D, Abou-Beih S, Watson R, Leslie J, Govaere O, Lunec J, Mann D, Nakjang S, Oakley F, Shukla R, Nakjang S, Anstee QM, Tiniakos D, Reeves HL |
| Citation(s) |
34408183 |
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| Submission date |
Sep 13, 2019 |
| Last update date |
Aug 24, 2021 |
| Contact name |
Helen Reeves |
| Organization name |
Northern Institute for Cancer Research
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| Department |
Faculty of Medical Sciences
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| Lab |
Paul O’Gorman Building
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| Street address |
Framlington Place
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| City |
Newcastle Upon Tyne |
| ZIP/Postal code |
NE2 4HH |
| Country |
United Kingdom |
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| Platforms (1) |
| GPL17021 |
Illumina HiSeq 2500 (Mus musculus) |
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| Samples (50)
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| GSM4078648 |
Liver, NT4_control-diet |
| GSM4078649 |
Liver, NT5_control-diet |
| GSM4078650 |
Liver, NT6_control-diet |
| GSM4078651 |
Liver, NT7_control-diet |
| GSM4078652 |
Liver, NT8_control-diet |
| GSM4078653 |
Liver, NT9_control-diet |
| GSM4078654 |
Liver, NT10_control-diet |
| GSM4078655 |
Liver, NT11_control-diet |
| GSM4078656 |
Liver, NT12_control-diet |
| GSM4078657 |
Liver, NT13_ALIOS-diet |
| GSM4078658 |
Liver, NT14_ALIOS-diet |
| GSM4078659 |
Liver, NT15_ALIOS-diet |
| GSM4078660 |
Liver, NT16_ALIOS-diet |
| GSM4078661 |
Liver, NT17_ALIOS-diet |
| GSM4078662 |
Liver, NT18_ALIOS-diet |
| GSM4078663 |
Liver, NT19_ALIOS-diet |
| GSM4078664 |
Liver, NT20_ALIOS-diet |
| GSM4078665 |
Liver, NT21_ALIOS-diet |
| GSM4078666 |
Liver, NT22_ALIOS-diet |
| GSM4078667 |
Liver, NT23_ALIOS-diet |
| GSM4078668 |
Liver, T1_ALIOS-diet |
| GSM4078669 |
Liver, T2_ALIOS-diet |
| GSM4078670 |
Liver, T3_ALIOS-diet |
| GSM4078671 |
Liver, T4_ALIOS-diet |
| GSM4078672 |
Liver, T5_ALIOS-diet |
| GSM4078673 |
Liver, T6_ALIOS-diet |
| GSM4078674 |
Liver, T7_control-diet |
| GSM4078675 |
Liver, T8_ALIOS-diet |
| GSM4078676 |
Liver, T9_ALIOS-diet |
| GSM4078677 |
Liver, T10_ALIOS-diet |
| GSM4078678 |
Liver, T11_ALIOS-diet |
| GSM4078679 |
Liver, T12_ALIOS-diet |
| GSM4078680 |
Liver, T13_ALIOS-diet |
| GSM4078681 |
Liver, T14_ALIOS-diet |
| GSM4078682 |
Liver, T15_ALIOS-diet/DEN |
| GSM4078683 |
Liver, T16_ALIOS-diet/DEN |
| GSM4078684 |
Liver, T17_control-diet/DEN |
| GSM4078685 |
Liver, T18_control-diet/DEN |
| GSM4078686 |
Liver, T19_control-diet/DEN |
| GSM4078687 |
Liver, T20_control-diet/DEN |
| GSM4078688 |
Liver, T21_control-diet/DEN |
| GSM4078689 |
Liver, T22_ALIOS-diet/DEN |
| GSM4078690 |
Liver, T23_ALIOS-diet/DEN |
| GSM4078691 |
Liver, T24_ALIOS-diet/DEN |
| GSM4078692 |
Liver, T25_ALIOS-diet/DEN |
| GSM4078693 |
Liver, T26_ALIOS-diet/DEN |
| GSM4078694 |
Liver, T27_ALIOS-diet/DEN |
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| Relations |
| BioProject |
PRJNA565390 |
| SRA |
SRP221582 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE137407_raw_counts.txt.gz |
1.8 Mb |
(ftp)(http) |
TXT |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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