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| Status |
Public on Sep 11, 2019 |
| Title |
MicroRNA Expression Profiles Analysis in Sperm Reveals miR-191 is an Auspicious Omen of in Vitro Fertilization |
| Organism |
Homo sapiens |
| Experiment type |
Non-coding RNA profiling by high throughput sequencing
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| Summary |
Background: MicroRNAs(miRNAs) are a class of non-coding small RNAs, which play important roles in many physiological processes by regulating gene expression. Previously studies show that the expression level of total miRNAs increased during the progression of mouse embryonic development, and some miRNAs control the regulatory network in the development progression.
Results: In this study,the results showed that the sperm samples with high expression of miR-191 had higher fertilization rate (FR), blastocyst rate (EER) and high-quality embryo rate (HQER).
Conclusions: These findings suggest that higher miR-191-5p expression with better human early embryonic development, and indicate that the miR-191-5p could be a potential marker to access the quality of IVF.
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| Overall design |
MicroRNA Expression Profiles of Sperm in Vitro Fertilization was generated by RNA-seq using HiSeq 2000
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| Contributor(s) |
Xu H, Wang X, Wang Z, Li J, Xu Z, Miao M, Chen G, Lei X, Wu J, Shi H, Wang K, Zhang T, Sun X |
| Citation(s) |
32066367 |
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| Submission date |
Sep 10, 2019 |
| Last update date |
Mar 02, 2020 |
| Contact name |
Zhang Tiancheng |
| E-mail(s) |
zhangtiancheng@sippr.org.cn
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| Organization name |
Shanghai institute of Planned Parenthood Research
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| Street address |
Xietu Road NO.2140
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| City |
Shanghai |
| ZIP/Postal code |
200031 |
| Country |
China |
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| Platforms (1) |
| GPL11154 |
Illumina HiSeq 2000 (Homo sapiens) |
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| Samples (102)
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| Relations |
| BioProject |
PRJNA564759 |
| SRA |
SRP221226 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE137182_RAW.tar |
220.0 Kb |
(http)(custom) |
TAR (of TXT) |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data provided as supplementary file |
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