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| Status |
Public on Dec 06, 2020 |
| Title |
Differential gene expression during embryoid body (EB) formation of mouse embryonic stem cells when Hnrnpll was depleted |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
This work indicates Hnrnpll depletion mES cells cannot exit from pluripotency programme, showing embryoid body formation deficiency and no spontaneous differentiation withdraw LIF. Hnrnpll promotes multiple ES cell preferred-exon skipping during ES cells differentiation, to reduce the ES cells specific isoform and facilitate ES cells exit from pluripotency towards differentiation.
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| |
|
| Overall design |
polyA+ RNA profiles of wildtype or Hnrnpll-/- mESC EB differentiation at day 0, 4, 8.
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| |
|
| Contributor(s) |
Wang X, Ping C, Tan P, Wang D, Ma Y, Yu J, Huang Y |
| Citation(s) |
33349972 |
| |
| Submission date |
Sep 05, 2019 |
| Last update date |
Jan 30, 2021 |
| Contact name |
Jia Yu |
| E-mail(s) |
j-yu@ibms.pumc.edu.cn
|
| Organization name |
Peking Union Medical College
|
| Street address |
Dong Dan San Tiao 5, Dongcheng District
|
| City |
Beijing |
| ZIP/Postal code |
100005 |
| Country |
China |
| |
|
| Platforms (1) |
| GPL21493 |
Illumina HiSeq 3000 (Mus musculus) |
|
| Samples (9)
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|
| Relations |
| BioProject |
PRJNA564112 |
| SRA |
SRP220502 |
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