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| Status |
Public on Nov 13, 2019 |
| Title |
Molecular profiling predicts meningioma recurrence and reveals loss of DREAM complex repression in aggressive tumors |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Meningiomas account for roughly one-third of all primary brain tumors. Although typically benign, about 20% of meningiomas are aggressive, and despite the rigor of the current histopathological classification system, there remains considerable uncertainty in predicting tumor behavior. Here we analyzed 160 tumors from all three WHO grades (I-III) using clinical, gene expression and sequencing data. Unsupervised clustering analysis identified three molecular groups that reliably predicted clinical severity. These groups did not directly correlate with the WHO grading system, which would classify more than half of the tumors in the most aggressive molecular group as benign. Transcriptional and biochemical analyses revealed that aggressive meningiomas involve loss of the repressor function of the DREAM complex, resulting in cell cycle activation, and only tumors in this group tend to recur after full resection. These findings should improve our ability to predict recurrence and develop targeted treatments for these clinically challenging tumors.
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| |
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| Overall design |
Discovery set: 97 tumors, Validation set: 48 tumors, Recurrence set: 15 tumors.
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| |
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| Contributor(s) |
Patel AJ, Wan YW, Zoghbi HY, Klisch TJ |
| Citation(s) |
31591222 |
| |
| Submission date |
Aug 29, 2019 |
| Last update date |
Nov 27, 2021 |
| Contact name |
Tiemo J Klisch |
| E-mail(s) |
klisch@bcm.edu
|
| Phone |
8328248885
|
| Organization name |
Baylor College of Medicine
|
| Department |
Department of Molecular and Human Genetics
|
| Lab |
Klisch
|
| Street address |
1250 Moursund Street, N1370.08
|
| City |
Houston |
| State/province |
Texas |
| ZIP/Postal code |
77030 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL20301 |
Illumina HiSeq 4000 (Homo sapiens) |
|
| Samples (160)
|
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| Relations |
| BioProject |
PRJNA563037 |
| SRA |
SRP219799 |
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