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Series GSE136661 Query DataSets for GSE136661
Status Public on Nov 13, 2019
Title Molecular profiling predicts meningioma recurrence and reveals loss of DREAM complex repression in aggressive tumors
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary Meningiomas account for roughly one-third of all primary brain tumors. Although typically benign, about 20% of meningiomas are aggressive, and despite the rigor of the current histopathological classification system, there remains considerable uncertainty in predicting tumor behavior. Here we analyzed 160 tumors from all three WHO grades (I-III) using clinical, gene expression and sequencing data. Unsupervised clustering analysis identified three molecular groups that reliably predicted clinical severity. These groups did not directly correlate with the WHO grading system, which would classify more than half of the tumors in the most aggressive molecular group as benign. Transcriptional and biochemical analyses revealed that aggressive meningiomas involve loss of the repressor function of the DREAM complex, resulting in cell cycle activation, and only tumors in this group tend to recur after full resection. These findings should improve our ability to predict recurrence and develop targeted treatments for these clinically challenging tumors.
 
Overall design Discovery set: 97 tumors, Validation set: 48 tumors, Recurrence set: 15 tumors.
 
Contributor(s) Patel AJ, Wan YW, Zoghbi HY, Klisch TJ
Citation(s) 31591222
Submission date Aug 29, 2019
Last update date Nov 27, 2021
Contact name Tiemo J Klisch
E-mail(s) klisch@bcm.edu
Phone 8328248885
Organization name Baylor College of Medicine
Department Department of Molecular and Human Genetics
Lab Klisch
Street address 1250 Moursund Street, N1370.08
City Houston
State/province Texas
ZIP/Postal code 77030
Country USA
 
Platforms (1)
GPL20301 Illumina HiSeq 4000 (Homo sapiens)
Samples (160)
GSM4054837 meningioma [DCC2]
GSM4054838 meningioma [DCC3]
GSM4054839 meningioma [14-04]
Relations
BioProject PRJNA563037
SRA SRP219799

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SOFT formatted family file(s) SOFTHelp
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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE136661_RAW.tar 31.8 Mb (http)(custom) TAR (of TXT)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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