|
| Status |
Public on Apr 15, 2020 |
| Title |
KSHV Requires vCyc to Overcome Replicative Senescence in Primary Human Lymphatic Endothelial Cells |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
We performed high throughput RNA-sequencing on KSHV-infected blood and lymphatic HMVECs at 48hpi as well as WTKSHV- or KSHVDvcyc-infected lymphatic HMVECS at 1wpi to identify differences in gene expression induced by KSHV in these two cell types and gene expression changes that require the KSHV latent gene vcyclin.
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| |
|
| Overall design |
RNA was isolated from 2 blood-specific HMVEC cell lines and 2 lymphatic-specific HMVEC cell lines 3 separate times each
|
| |
|
| Contributor(s) |
DiMaio T, Lagunoff M |
| Citation(s) |
32555637 |
| |
| Submission date |
Aug 29, 2019 |
| Last update date |
Jul 13, 2020 |
| Contact name |
Terri DiMaio |
| E-mail(s) |
tdimaio@uw.edu
|
| Phone |
206-221-5693
|
| Organization name |
University of Washington
|
| Department |
Microbiology
|
| Lab |
Lagunoff
|
| Street address |
750 Republican St.
|
| City |
Seattle |
| State/province |
WA |
| ZIP/Postal code |
98109 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL11154 |
Illumina HiSeq 2000 (Homo sapiens) |
|
| Samples (12)
|
|
| Relations |
| BioProject |
PRJNA562924 |
| SRA |
SRP219849 |
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