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Series GSE136161 Query DataSets for GSE136161
Status Public on May 26, 2021
Title Terminal uridyltransferase 7 regulates TLR4-triggered inflammation by controlling Regnase-1 mRNA uridylation and degradation
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary We revealed that the transcriptome of the mammalian cells under inflammatory status using RNA Sequencing (RNA-Seq). The transcriptome of BMDMs from wild-type and Tut7-/- was compared to baseline. The fold-change was presented by the logarithm of p-values to the base 2 and the significance was presented by the negative logarithm of that to the base 10. log2FC > +0.2 and log2FC < -0.2 indicate the increase of transcript levels by >20% and decreased by >20%, respectively. Among the 352 genes, 111 of them involving in innate immune response were downregulated in Tut7-/- cells.
Overall design LPS-induced BMDMs mRNA profiles of 7-week-old wild type and Tut7-/- mice were generated by deep sequencing, in duplicate, using Illumina HiSeq PE150
Contributor(s) Lin C
Citation(s) 34188032
Submission date Aug 21, 2019
Last update date Jul 27, 2021
Contact name Li-Chung Hsu
Phone +886-2-23123456
Organization name National Taiwan University
Department Graduate institute of Molecular Medicine
Street address No.7, ChungShan S. Rd., ZhongZheng Dist.
City Taipei
ZIP/Postal code 10002
Country Taiwan
Platforms (1)
GPL21273 HiSeq X Ten (Mus musculus)
Samples (8)
GSM4041820 BMDMs, WT-Ctrl_1
GSM4041821 BMDMs, WT-Ctrl_2
GSM4041822 BMDMs, WT-LPS_1
BioProject PRJNA561406
SRA SRP219042

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Supplementary file Size Download File type/resource
GSE136161_RC_RPKM.xlsx 4.7 Mb (ftp)(http) XLSX
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Raw data are available in SRA
Processed data are available on Series record

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