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| Status |
Public on May 26, 2021 |
| Title |
Terminal uridyltransferase 7 regulates TLR4-triggered inflammation by controlling Regnase-1 mRNA uridylation and degradation |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
We revealed that the transcriptome of the mammalian cells under inflammatory status using RNA Sequencing (RNA-Seq). The transcriptome of BMDMs from wild-type and Tut7-/- was compared to baseline. The fold-change was presented by the logarithm of p-values to the base 2 and the significance was presented by the negative logarithm of that to the base 10. log2FC > +0.2 and log2FC < -0.2 indicate the increase of transcript levels by >20% and decreased by >20%, respectively. Among the 352 genes, 111 of them involving in innate immune response were downregulated in Tut7-/- cells.
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| Overall design |
LPS-induced BMDMs mRNA profiles of 7-week-old wild type and Tut7-/- mice were generated by deep sequencing, in duplicate, using Illumina HiSeq PE150
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| |
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| Contributor(s) |
Lin C |
| Citation(s) |
34188032 |
| |
| Submission date |
Aug 21, 2019 |
| Last update date |
Jul 27, 2021 |
| Contact name |
Li-Chung Hsu |
| E-mail(s) |
lichunghsu@ntu.edu.tw
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| Phone |
+886-2-23123456
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| Organization name |
National Taiwan University
|
| Department |
Graduate institute of Molecular Medicine
|
| Street address |
No.7, ChungShan S. Rd., ZhongZheng Dist.
|
| City |
Taipei |
| ZIP/Postal code |
10002 |
| Country |
Taiwan |
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| Platforms (1) |
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| Samples (8)
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| Relations |
| BioProject |
PRJNA561406 |
| SRA |
SRP219042 |
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