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| Status |
Public on Sep 30, 2019 |
| Title |
Placental Accreta Spectrum: Upregulated Cytotrophoblast DOCK4 Contributes to Over Invasion |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
In humans, a subset of placental cytotrophoblasts (CTBs) invades the uterus and its vasculature, anchoring the pregnancy and ensuring adequate blood flow to the fetus. Appropriate depth is critical. Shallow invasion increases the risk of pregnancy complications, e.g., severe preeclampsia. Overly deep invasion, the hallmark of placenta accreta spectrum (PAS), increases the risk of pre-term delivery, hemorrhage and death. Previously a rare condition, the incidence of PAS has increased to 1:731 pregnancies, likely due to the rise in uterine surgeries (e.g., Cesarean sections). CTBs track along the scars deep into the myometrium and beyond. Here we compared the global gene expression patterns of CTBs from PAS cases to gestational age-matched control cells that invaded to the normal depth from preterm birth (PTB) deliveries. The mRNA encoding the guanine nucleotide exchange factor, DOCK4, mutations of which promote cancer cell invasion and angiogenesis, was the most highly differentially expressed molecule in PAS samples. Over-expression of DOCK4 increased CTB invasiveness, consistent with the PAS phenotype. Also, this analysis identified other genes with significantly altered expression in this disorder, potential biomarkers. These data suggest that CTBs from PAS cases up regulate a cancer-like pro-invasion mechanism, suggesting molecular as well as phenotypic similarities in the two pathologies.
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| Overall design |
Expression profiling of placental cytotrophoblasts from PAS patients and healthy controls.
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| Contributor(s) |
McNally L, Zhou Y, Robinson JF, Zhao G, Chen L, Chen H, Kim MY, Kapidzic M, Gormley M, Fisher SJ |
| Citation(s) |
32576693 |
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| Submission date |
Aug 20, 2019 |
| Last update date |
Jul 27, 2020 |
| Contact name |
M. Yvonne Kim |
| E-mail(s) |
yvonne.kim@ucsf.edu
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| Organization name |
UC San Francisco
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| Street address |
3rd st.
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| City |
San Francisco |
| State/province |
CA |
| ZIP/Postal code |
94143 |
| Country |
USA |
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| Platforms (1) |
| GPL17586 |
[HTA-2_0] Affymetrix Human Transcriptome Array 2.0 [transcript (gene) version] |
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| Samples (9)
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| Relations |
| BioProject |
PRJNA561109 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE136048_RAW.tar |
210.5 Mb |
(http)(custom) |
TAR (of CEL) |
| GSE136048_accreta_output.txt.gz |
7.1 Mb |
(ftp)(http) |
TXT |
| Processed data included within Sample table |
| Processed data are available on Series record |
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