GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
Series GSE136001 Query DataSets for GSE136001
Status Public on Nov 04, 2020
Title Single cell RNA sequencing reveals functional heterogeneity and sex differences of glioma-associated brain macrophages
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Single cell RNA-seq analysis of CD11b+ cells sorted from murine syngeneic gliomas, indicating distinct activity of microglia, infiltrating monocytes/macrophages and CNS border associated macrophages. It demonstrates a molecular heterogeneity in the innate immune response in gliomas. Differently expressed genes were identified in activated microglia from glioma-bearing mice of different sex, and profound overexpression of the MHCII genes was observed in male microglial cells.
Overall design Single cell RNA sequencing analysis of 4 groups: female control (2 samples), female tumor (14 days post implantation, 2 samples), male control (2 samples), male tumor (14 days post implantation, 2 samples).
Contributor(s) Ochocka N, Segit P, Walentynowicz KA, Wojnicki K, Cyranowski S, Swatler J, Mieczkowski J, Kaminska B
Citation(s) 33608526
Submission date Aug 19, 2019
Last update date Mar 10, 2021
Contact name Jakub Mieczkowski
Organization name Medical University of Gdansk
Street address Debinki 12
City Gdansk
ZIP/Postal code 80-211
Country Poland
Platforms (1)
GPL18480 Illumina HiSeq 1500 (Mus musculus)
Samples (8)
GSM4039241 F-ctrl-1
GSM4039242 F-ctrl-2
GSM4039243 F-tumor-1
BioProject PRJNA560921
SRA SRP218842

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE136001_RAW.tar 140.1 Mb (http)(custom) TAR (of MTX, TSV)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap