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| Status |
Public on Sep 02, 2020 |
| Title |
A single cell approach to map cellular subsets involved in Systemic Lupus Erythematosus (SLE) heterogeneity |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
In this study, we analyzed the transcriptomes of ~276k single PBMCs from 33 childhood SLE (cSLE) and 11 healthy matched donors (cHD). Our findings were validated in an independent cohort including 8 adult SLE (aSLE) patients and 6 matched controls (aHD; ~132k PBMCs).
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| Overall design |
cSLE dataset included 33 cSLE (cSLE1 to cSLE33). 11 cHD controles (cHD1 to cHD11) aSLE dataset included 8 aSLE (aSLE1 to aSLE8) and 6 aHD controles (aHD1 to aHD6). Clinical information to be found in supplementary table 1.
**The raw data have been deposited in dbGaP (Study accession: phs002048.v1.p1) due to patient privacy concerns.**
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| Contributor(s) |
Nehar-Belaid D, Flynn WF, Banchereau J, Pascual V, Robson P |
| Citation(s) |
32747814 |
| NIH grant(s) |
| Grant ID |
Grant title |
Affiliation |
Name |
| P50 AR070594 |
Center for Lupus Research |
WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY |
Maria Virginia Pascual |
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| |
| Submission date |
Aug 13, 2019 |
| Last update date |
Dec 02, 2020 |
| Contact name |
William F Flynn |
| Organization name |
The Jackson Laboratory
|
| Street address |
10 Discovery Drive
|
| City |
Farmington |
| State/province |
CT |
| ZIP/Postal code |
06032 |
| Country |
USA |
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| Platforms (1) |
| GPL20301 |
Illumina HiSeq 4000 (Homo sapiens) |
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| Samples (56)
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| Relations |
| BioProject |
PRJNA560047 |
| SRA |
SRP218234 |
| SRA |
SRP279678 |
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