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Series GSE135400 Query DataSets for GSE135400
Status Public on Jun 01, 2021
Title KDM1B is an important regulator of cytokine signaling in the tumor immune microenvironment and response to immune checkpoint therapy (RNA-seq)
Organisms Homo sapiens; Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Tumor microenvironment (TME) plays an important role in immune evasion and resistance to immune checkpoint therapy. Here, by using genetic, epigenetic, tumor biology and immunology approaches, we unraveled a key function of KDM1B in TME. KDM1B is important for maintaining several pro-oncogenic cytokine/chemokine signaling pathways. In vivo in resistant and inflammatory breast cancer models, ablation of KDM1B in tumor cells results in increased T cell activity and significantly improved response to anti-PD-1/anti-CTLA-4 therapy. Thus, this study identifies KDM1B as a key regulator of tumor immune microenvironment and offered the mechanistical basis for using KDM1B inhibitors in combinatory therapy to overcome resistance to immune checkpoint blockade.
Overall design Use transcriptom analysis to examine the effect of KDM1B depletion to cancer cell in culture and tumors developed from s.q cancer cell injection.
Contributor(s) Fang R, Shi Y
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Submission date Aug 05, 2019
Last update date Jun 01, 2021
Contact name Yujiang Shi
Phone 617-525-8097
Organization name Brigham and Women's Hospital
Department Division of Endocrinology, Diabetes and Hypertension
Street address 221 longwood Ave, EBRC (LMRC) 222A
City Boston
State/province MA
ZIP/Postal code 02115
Country USA
Platforms (2)
GPL20795 HiSeq X Ten (Homo sapiens)
GPL21273 HiSeq X Ten (Mus musculus)
Samples (19)
GSM4007665 4T1_tumor_WT_1
GSM4007666 4T1_tumor_WT_2
GSM4007667 4T1_tumor_WT_3
BioProject PRJNA558763
SRA SRP217501

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Supplementary file Size Download File type/resource
GSE135400_Expression_FPKM_Count_4T1_tumor_WT_KDM1BKO_KDM1AKO.txt.gz 2.9 Mb (ftp)(http) TXT
GSE135400_Expression_FPKM_Count_MDA231_cell_WT_KDM1BKO.txt.gz 2.3 Mb (ftp)(http) TXT
GSE135400_Expression_FPKM_Count_MDA231_tumor_WT_KDM1BKO.txt.gz 2.8 Mb (ftp)(http) TXT
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Processed data are available on Series record

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